Scox Synthesis of cytochrome c oxidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Scoxprovided by FlyBase
Official Full Name: Synthesis of cytochrome c oxidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0262467
Locus tag: Dmel_CG8885
See related: AllianceGenome:FB:FBgn0262467
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8885; Dmel\CG8885; dSco1; l(2)SH1783; l(2)SH2 1783; SCO; SCO1; scox; SCOX
Summary: Predicted to enable copper chaperone activity and copper ion binding activity. Involved in cytochrome complex assembly and positive regulation of ATP biosynthetic process. Predicted to be located in mitochondrion. Is expressed in adult head; adult heart; nurse cell; oocyte; and organism. Used to study cytochrome-c oxidase deficiency disease; mitochondrial complex IV deficiency nuclear type 4; neurodegenerative disease; and retinal degeneration. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; hypertrophic cardiomyopathy; mitochondrial complex IV deficiency nuclear type 2; mitochondrial complex IV deficiency nuclear type 4; and myopia. Orthologous to several human genes including SCO1 (synthesis of cytochrome C oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25B5-25B5; 2-14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4967832..4968935, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4967832..4968935, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The function of Scox in glial cells is essential for locomotive ability in Drosophila.
Title: The function of Scox in glial cells is essential for locomotive ability in Drosophila.
Dp53 is directly involved in the development of the cardiomyopathy induced by scox deficiency.
Title: Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.
the identification and characterization of scox, the single Drosophila melanogaster SCO-encoding gene
Title: Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables copper chaperone activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytochrome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular copper ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in respiratory chain complex IV assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info