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    rpl4 ribosomal protein L4 [ Danio rerio (zebrafish) ]

    Gene ID: 337090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpl4provided by ZNC
    Official Full Name
    ribosomal protein L4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9034
    See related
    Ensembl:ENSDARG00000041182 AllianceGenome:ZFIN:ZDB-GENE-030131-9034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa97a02; fl04b10; zgc:56659; zgc:85693; wu:fa97a02; wu:fa97c01; wu:fl04b10
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in digestive system; endodermal cell; and eye. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rpl4 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (19451166..19456201, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (19462100..19467135, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488273 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene small nucleolar RNA SNORD18 Neighboring gene small nucleolar RNA SNORD18 Neighboring gene small nucleolar RNA SNORD18 Neighboring gene small nucleolar RNA SNORA35 Neighboring gene small nucleolar RNA SNORD16 Neighboring gene small nucleolar RNA SNORD18 Neighboring gene small nucleolar RNA SNORD16 Neighboring gene zwilch kinetochore protein Neighboring gene lactase-like b Neighboring gene small nuclear RNA activating complex, polypeptide 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development. Ates KM, et al. Dis Model Mech, 2020 May 26. PMID 32152089, Free PMC Article
    2. Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation. Lu PN, et al. JCI Insight, 2020 Oct 15. PMID 33055423, Free PMC Article
    3. Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders. Lee JJ, et al. iScience, 2024 Apr 19. PMID 38495824, Free PMC Article
    4. TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development. Flanagan-Steet H, et al. Cell Rep, 2018 Mar 13. PMID 29539424, Free PMC Article
    5. Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Liu Q, et al. Reprod Toxicol, 2016 Oct. PMID 27544571

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213107.1 → NP_998272.1  large ribosomal subunit protein uL4

      See identical proteins and their annotated locations for NP_998272.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049520
      UniProtKB/TrEMBL
      F6PAP4, Q1LUY4, Q7ZW95
      Related
      ENSDARP00000060362.4, ENSDART00000060363.5
      Conserved Domains (2) summary
      pfam14374
      Location:276 → 344
      Ribos_L4_asso_C; 60S ribosomal protein L4 C-terminal domain
      cl00325
      Location:10 → 265
      Ribosomal_L4; Ribosomal protein L4/L1 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      19451166..19456201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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