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    Cf2 Chorion factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cf2provided by FlyBase
    Official Full Name
    Chorion factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0000286
    Locus tag
    Dmel_CG11924
    See related
    AllianceGenome:FB:FBgn0000286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM09668; CF-2; cf2; CF2; CF2.5; Cf2_II; CG11924; Dmel\CG11924
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including adult somatic muscle development; dorsal appendage formation; and positive regulation of transcription elongation by RNA polymerase II. Located in cytosol and nucleus. Is expressed in several structures, including egg chamber; embryonic dorsal vessel; gonad; mesoderm; and muscle cell. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cf2 in Genome Data Viewer
    Location:
    25B1-25B1; 2-14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4876891..4883107, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4876891..4883107, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Monensin sensitivity 1 Neighboring gene smog Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recognition of diverse sequences by class I zinc fingers: asymmetries and indirect effects on specificity in the interaction between CF2II and A+T-rich elements. Gogos JA, et al. Proc Natl Acad Sci U S A, 1996 Mar 5. PMID 8700901, Free PMC Article
    2. Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain. Gogos JA, et al. Science, 1992 Sep 25. PMID 1290524
    3. Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene. Hsu T, et al. Science, 1992 Sep 25. PMID 1411512
    4. The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Bagni C, et al. Mech Dev, 2002 Sep. PMID 12204268
    5. CF2 transcription factor is involved in the regulation of Mef2 RNA levels, nuclei number and muscle fiber size. Arredondo JJ, et al. PLoS One, 2017. PMID 28617826, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CF2 expression variations yield altered Mef2 expression levels but with correct spatio-temporal Mef2 expression patterns, it can be concluded that only the mechanism controlling expression levels is de-regulated. Here, it is proposed that CF2 regulates Mef2 expression through a Feedforward Loop circuit.
      Title: CF2 transcription factor is involved in the regulation of Mef2 RNA levels, nuclei number and muscle fiber size.
    2. These results indicate a role for CF2 as a direct negative regulator of the thin filament protein gene Actin 88F.
      Title: CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila.
    3. CF2 depletion alters the relative expression of thin and thick filament components of muscle.
      Title: CF2 activity and enhancer integration are required for proper muscle gene expression in Drosophila.
    4. Mef2 and Cf2 collaborate in activation of the myogenic program in Drosophila.
      Title: Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila.
    5. CF2 expression during muscle development is dependent on the myogenic factor MEF2.
      Title: The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chorion factor 2
    Names
    CG11924-PA
    CG11924-PB
    CG11924-PC
    CG11924-PE
    CG11924-PF
    CG11924-PG
    Cf2-PA
    Cf2-PB
    Cf2-PC
    Cf2-PE
    Cf2-PF
    Cf2-PG
    chorion Factor-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4876891..4883107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_175963.3 → NP_787977.2  chorion factor 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787977.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20385
      Conserved Domains (4) summary
      COG5048
      Location:366 → 473
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:401 → 423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:443 → 468
      zf-H2C2_2; Zinc-finger double domain

    2. NM_175964.2 → NP_787978.1  chorion factor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787978.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20385
      Related
      FBpp0088591
      Conserved Domains (4) summary
      COG5048
      Location:366 → 473
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:401 → 423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:443 → 468
      zf-H2C2_2; Zinc-finger double domain

    3. NM_078750.4 → NP_523474.1  chorion factor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20385, Q01522, Q0IGV4, Q24263, Q5U0W7, Q86BN0, Q86BN1, Q9VR41
      Related
      FBpp0088592
      Conserved Domains (4) summary
      COG5048
      Location:365 → 503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:401 → 423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:471 → 496
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001273128.1 → NP_001260057.1  chorion factor 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB35
      Conserved Domains (4) summary
      COG5048
      Location:315 → 422
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:352 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:350 → 372
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:392 → 417
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001363925.1 → NP_001350854.1  chorion factor 2, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2U8U0H6
      Conserved Domains (3) summary
      COG5048
      Location:366 → 473
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:443 → 468
      zf-H2C2_2; Zinc-finger double domain

    6. NM_175965.2 → NP_787979.1  chorion factor 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20385
      Related
      FBpp0088590
      Conserved Domains (4) summary
      COG5048
      Location:366 → 473
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:401 → 423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:443 → 468
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A2U8U0H6 A0A2U8U0H6
    M9PB35 M9PB35
    P20385.3 P20385
    Q8T3L9 Q8T3L9

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