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    Elp3 Elongator complex protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33649, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Elp3provided by FlyBase
    Official Full Name
    Elongator complex protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031604
    Locus tag
    Dmel_CG15433
    See related
    AllianceGenome:FB:FBgn0031604
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15433; D-elp3; Dmel/ELP3; Dmel\CG15433; Dmel\ELP3; dmHAG408; elp-3; elp3; ELP3; HAT
    Summary
    Enables tRNA N-acetyltransferase activity. Involved in several processes, including cytoskeleton organization; long-term memory; and synaptic assembly at neuromuscular junction. Located in cytoplasm and synapse. Part of elongator holoenzyme complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human ELP3 (elongator acetyltransferase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Elp3 in Genome Data Viewer
    Location:
    24F2-24F2; 2-12 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4444732..4446765)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4444732..4446765)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Seminal fluid protein 24F Neighboring gene uncharacterized protein Neighboring gene modifier of rpr and grim, ubiquitously expressed Neighboring gene Major Facilitator Superfamily Transporter 18 Neighboring gene uncharacterized protein Neighboring gene tRNA Selenocysteine associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elongator complex is required for long-term olfactory memory formation in Drosophila. Yu D, et al. Learn Mem, 2018 Apr. PMID 29545390, Free PMC Article
    2. The cloning and characterization of the histone acetyltransferase human homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 is essential for multicellular development. Zhu X, et al. Genetics, 2007 Mar. PMID 17179074, Free PMC Article
    3. Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Simpson CL, et al. Hum Mol Genet, 2009 Feb 1. PMID 18996918, Free PMC Article
    4. DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5. Kendek A, et al. Nucleic Acids Res, 2024 Oct 28. PMID 39258543, Free PMC Article
    5. The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory. Perry S, et al. Cell Rep, 2017 Feb 7. PMID 28178513, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the Elongator complex (elp3 and elp1) is required in adult mushroom body neurons for long-term behavioral memory and the associated long-term memory trace.
      Title: Elongator complex is required for long-term olfactory memory formation in Drosophila.
    2. The results of this study proposed a model where ELP3-dependent acetylation of Bruchpilot at synapses regulates the structure of individual presynaptic densities and neurotransmitter release efficiency.
      Title: ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.
    3. Elp3 is essential for viability, normal development, and hematopoiesis and suggest a functional overlap with the chromatin remodeler Domino.
      Title: Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity.
    4. ELP3 is important in neuronal communication and survival.
      Title: Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorylase kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeletal matrix organization at active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle asymmetry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    elongator complex protein 3
    Names
    CG15433-PA
    Elp3-PA
    elongator protein 3
    NP_608834.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4444732..4446765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134990.3 → NP_608834.1  elongator complex protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQZ6
      Related
      FBpp0077129
      Conserved Domains (1) summary
      TIGR01211
      Location:23 → 548
      ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQZ6.1 Q9VQZ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools