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    nfil3-5 nuclear factor, interleukin 3 regulated, member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 335737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nfil3-5provided by ZNC
    Official Full Name
    nuclear factor, interleukin 3 regulated, member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7677
    See related
    Ensembl:ENSDARG00000094965 AllianceGenome:ZFIN:ZDB-GENE-030131-7677
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    E4BP4-5; wu:fk63e10; si:dkey-52h23.1
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within circadian regulation of gene expression and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in epiphysis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nfil3-5 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (8172224..8180042)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7936390..7944503)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495917 Neighboring gene Kruppel like factor 1 (erythroid) Neighboring gene nuclear factor, interleukin 3 regulated, member 3 Neighboring gene ral guanine nucleotide dissociation stimulator-like 3a Neighboring gene outer dynein arm docking complex subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and expression of lypc, a novel dark-inducible member of Ly6 superfamily in zebrafish Danio rerio. Li L, et al. Gene, 2015 Dec 10. PMID 26278158
    2. MiR-202-3p determines embryo viability during mid-blastula transition. Hu R, et al. Front Cell Dev Biol, 2022. PMID 36003151, Free PMC Article
    3. Loss of circadian rhythmicity in bdnf knockout zebrafish larvae. D'Agostino Y, et al. iScience, 2022 Apr 15. PMID 35345456, Free PMC Article
    4. Multiple PAR and E4BP4 bZIP transcription factors in zebrafish: diverse spatial and temporal expression patterns. Ben-Moshe Z, et al. Chronobiol Int, 2010 Sep. PMID 20854132
    5. The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Ben-Moshe Z, et al. Nucleic Acids Res, 2014 Apr. PMID 24423866, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear factor, interleukin 3 regulated, member 5
    Names
    E4 binding protein 4-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197058.1 → NP_001183987.1  nuclear factor, interleukin 3 regulated, member 5

      Status: PROVISIONAL

      Source sequence(s)
      BC060943
      UniProtKB/TrEMBL
      A0A8M1NV59, Q6P933
      Related
      ENSDARP00000147013.1, ENSDART00000193308.1
      Conserved Domains (1) summary
      cd14694
      Location:63 → 122
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      8172224..8180042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165724.5 → XP_005165781.1  nuclear factor, interleukin 3 regulated, member 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5Z5, F1QZP2, Q6P933
      Related
      ENSDARP00000117561.1, ENSDART00000146106.2
      Conserved Domains (1) summary
      cd14694
      Location:63 → 122
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain

    2. XM_068221654.1 → XP_068077755.1  nuclear factor, interleukin 3 regulated, member 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5Z5, F1QZP2, Q6P933

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394626.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      925..4385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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