U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CG40160 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354965, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG40160provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0058160
    Locus tag
    Dmel_CG40160
    See related
    AllianceGenome:FB:FBgn0058160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD13269; cSPH242; Dmel\CG40160
    Summary
    Enables peptidase activator activity. Involved in melanization defense response and zymogen activation. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG40160 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (26215815..26229433)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (1562357..1575983)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lethal (3) 80Fg Neighboring gene antisense RNA:CR45182 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster. Jin Q, et al. Front Immunol, 2023. PMID 37781370, Free PMC Article
    2. Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine. Zhang CH, et al. J Insect Sci, 2019 May 1. PMID 31115476, Free PMC Article
    3. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article
    4. The Drosophila Tis11 protein and its effects on mRNA expression in flies. Choi YJ, et al. J Biol Chem, 2014 Dec 19. PMID 25342740, Free PMC Article
    5. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
      Title: Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zymogen activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG40160-PA
    CG40160-PD
    CG40160-PE
    CG40160-PF
    CG40160-PG
    CG40160-PH

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      26215815..26229433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276236.1 → NP_001263165.1  uncharacterized protein Dmel_CG40160, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y546, Q95RS6
      Conserved Domains (2) summary
      smart00020
      Location:169 → 405
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:166 → 408
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001170384.1 → NP_001163855.1  uncharacterized protein Dmel_CG40160, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y546, Q95RS6
      Conserved Domains (2) summary
      smart00020
      Location:169 → 405
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:166 → 408
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_001015212.4 → NP_001015212.1  uncharacterized protein Dmel_CG40160, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y546, Q95RS6
      Conserved Domains (2) summary
      smart00020
      Location:169 → 405
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:166 → 408
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. NM_001170385.2 → NP_001163856.1  uncharacterized protein Dmel_CG40160, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y546, Q95RS6
      Conserved Domains (2) summary
      smart00020
      Location:169 → 405
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:166 → 408
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    5. NM_001015213.4 → NP_001015213.3  uncharacterized protein Dmel_CG40160, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015213.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y546, Q95RS6
      Conserved Domains (2) summary
      smart00020
      Location:169 → 405
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:166 → 408
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    6. NM_001015214.4 → NP_001015214.1  uncharacterized protein Dmel_CG40160, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y546, Q95RS6
      Conserved Domains (2) summary
      smart00020
      Location:169 → 405
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:166 → 408
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RS6 Q95RS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools