agr1 anterior gradient 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: agr1provided by ZNC
Official Full Name: anterior gradient 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7249
See related: Ensembl:ENSDARG00000060682 AllianceGenome:ZFIN:ZDB-GENE-030131-7249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ag1; fl24a12; wu:fl24a12; zgc:165571
Summary: Acts upstream of or within fin regeneration. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including EVL; digestive system; fin; oral epithelium; and sensory system. Orthologous to human AGR3 (anterior gradient 3, protein disulphide isomerase family member). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (45591229..45603006, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (45790750..45802527, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data confirm that reduction of the regenerative abilities in higher vertebrates, including human, could be explained by extinction of some genes essential for the regeneration, in particular, of ag1.
Title: [ag1 Is Required for the Fin Regeneration in Danio rerio].
The loss of Ag1 in higher vertebrates ancestors could lead to the reduction of the regenerative capacity in their modern descendants.
Title: The secreted factor Ag1 missing in higher vertebrates regulates fins regeneration in Danio rerio.

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General gene information

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Markers

fl24a12.x1 (e-PCR)
- UniSTS:202081

fj21e10.x1 (e-PCR)
- UniSTS:198768

fj07g01.x1 (e-PCR)
- UniSTS:188398

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: anterior gradient 1

Names: DAg1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099232.2 → NP_001092702.2 anterior gradient 1 precursor

Status: VALIDATED

Source sequence(s)

EH452502, EH464266

UniProtKB/TrEMBL

F1Q8B0, M1FZZ1

Related

ENSDARP00000080198.5, ENSDART00000085763.7

Conserved Domains (1) summary

cd02960
Location:33 → 162

AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...