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    Rab3GAP1 RAB3 GTPase activating protein subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33338, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab3GAP1provided by FlyBase
    Official Full Name
    RAB3 GTPase activating protein subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0051935
    Locus tag
    Dmel_CG31935
    See related
    AllianceGenome:FB:FBgn0051935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10870; CG31935; CG7373; Dmel\CG31935
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in macroautophagy. Predicted to be located in endoplasmic reticulum tubular network. Predicted to be part of protein-containing complex. Used to study Warburg micro syndrome. Human ortholog(s) of this gene implicated in Warburg micro syndrome 1. Orthologous to human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Rab3GAP1 in Genome Data Viewer
    Location:
    22A3-22A3; 2-3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1594822..1611157, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1594822..1611157, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Odorant receptor 22b Neighboring gene hattifattener Neighboring gene no individualized sperm Neighboring gene long non-coding RNA:CR44603 Neighboring gene uncharacterized protein Neighboring gene Rieske iron-sulfur protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in establishment of protein localization to endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid droplet organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endoplasmic reticulum tubular network organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of calcium ion-dependent exocytosis of neurotransmitter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of short-term neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum tubular network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    RAB3 GTPase activating protein subunit 1
    Names
    CG31935-PA
    RAB3 GTPase activating protein catalytic subunit 1
    Rab3GAP1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1594822..1611157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134764.3NP_608608.2  RAB3 GTPase activating protein subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608608.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ26
      Related
      FBpp0077582
      Conserved Domains (1) summary
      pfam13890
      Location:578726
      Rab3-GTPase_cat; Rab3 GTPase-activating protein catalytic subunit