Shisa3 shisa family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shisa3provided by MGI
Official Full Name: shisa family member 3provided by MGI
Primary source: MGI:MGI:3041225
See related: Ensembl:ENSMUSG00000050010 AllianceGenome:MGI:3041225
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D830007B15Rik
Summary: Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including brain; cranium; embryo mesenchyme; future brain; and gut. Orthologous to human SHISA3 (shisa family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 11.0), frontal lobe adult (RPKM 5.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.1; 5 36.15 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (67765226..67771330)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (67607883..67613987)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHISA3 is normally expressed in the developing heart and is up-regulated in pathological remodeling.
Title: KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart.
here appears to be a redundancy in the function of Shisa3 in bone development, likely with other Shisa family members.
Title: The Shisa3 knockout mouse exhibits normal bone phenotype.
Shisa3 acts as a tumor suppressor by acceleration of beta-catenin degradation. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201312-2256OC
Title: Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein shisa-3 homolog

Names: shisa homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.