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    Csmd2 CUB and Sushi multiple domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 329942, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Csmd2provided by MGI
    Official Full Name
    CUB and Sushi multiple domains 2provided by MGI
    Primary source
    MGI:MGI:2386401
    See related
    Ensembl:ENSMUSG00000028804 AllianceGenome:MGI:2386401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm139
    Summary
    Involved in maintenance of postsynaptic density structure and postsynaptic density assembly. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in central nervous system and ganglia. Orthologous to human CSMD2 (CUB and Sushi multiple domains 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.4), whole brain E14.5 (RPKM 3.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csmd2 in Genome Data Viewer
    Location:
    4 D2.2; 4 61.65 cM
    Exon count:
    72
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (127880310..128461459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (127986505..128567660)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11449 Neighboring gene predicted gene, 40256 Neighboring gene cDNA sequence CK137956 Neighboring gene predicted gene, 38571 Neighboring gene STARR-seq mESC enhancer starr_11450 Neighboring gene STARR-seq mESC enhancer starr_11451 Neighboring gene STARR-seq mESC enhancer starr_11452 Neighboring gene high-mobility group box 4, opposite strand Neighboring gene high-mobility group box 4 Neighboring gene STARR-seq mESC enhancer starr_11453 Neighboring gene predicted gene, 33656 Neighboring gene STARR-positive B cell enhancer ABC_E839 Neighboring gene zinc finger and SCAN domains 20 Neighboring gene toll-like receptor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation. Gutierrez MA, et al. eNeuro, 2019 Mar/Apr. PMID 31068362, Free PMC Article
    2. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Csmd2 plays a role in development and maintenance of dendrites and synapses.
      Title: Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1884, B230311I21, B230378I17

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in maintenance of postsynaptic density structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of postsynaptic density structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic density assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic density assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CUB and sushi domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281955.1 → NP_001268884.1  CUB and sushi domain-containing protein 2

      Status: PROVISIONAL

      Source sequence(s)
      AL611934, AL611969, AL627093, AL807807, AL928698, AL954639
      Consensus CDS
      CCDS84795.1
      UniProtKB/TrEMBL
      V9GX34
      Related
      ENSMUSP00000138958.3, ENSMUST00000184063.3
      Conserved Domains (6) summary
      cd00033
      Location:3136 → 3189
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:184 → 241
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2658 → 2894
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:623 → 730
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:2297 → 2354
      Sushi; Sushi repeat (SCR repeat)
      pfam00431
      Location:1490 → 1595
      CUB; CUB domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      127880310..128461459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240560.4 → XP_011238862.1  CUB and sushi domain-containing protein 2 isoform X1

      Conserved Domains (6) summary
      cd00033
      Location:2959 → 3012
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:184 → 241
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2658 → 2894
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:623 → 730
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:2297 → 2354
      Sushi; Sushi repeat (SCR repeat)
      pfam00431
      Location:1490 → 1595
      CUB; CUB domain

    2. XM_036164198.1 → XP_036020091.1  CUB and sushi domain-containing protein 2 isoform X2

      Conserved Domains (5) summary
      cd00033
      Location:566 → 620
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:184 → 241
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      cd00041
      Location:623 → 730
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:2126 → 2181
      Sushi; Sushi repeat (SCR repeat)
      pfam00431
      Location:1490 → 1595
      CUB; CUB domain

    RNA

    1. XR_001784158.3 RNA Sequence

    2. XR_001784159.3 RNA Sequence

    3. XR_001784160.3 RNA Sequence

    4. XR_867884.4 RNA Sequence

    5. XR_003954975.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033413.1: Suppressed sequence

      Description
      NM_001033413.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials