Parp4 poly (ADP-ribose) polymerase family, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp4provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 4provided by MGI
Primary source: MGI:MGI:2685589
See related: Ensembl:ENSMUSG00000054509 AllianceGenome:MGI:2685589
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PH5P; p193; ARTD4; Gm743; PARPL; VPARP; PARP-4; VAULT3; Adprtl1; C030027K23Rik; E230037B21Rik
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Predicted to be involved in inflammatory response and protein modification process. Predicted to be located in cytosol; nucleoplasm; and spindle microtubule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in cerebral cortex. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 5.9), placenta adult (RPKM 4.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.31 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56812982..56897256)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (56575619..56659798)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within telomere maintenance via telomerase	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in spindle	TAS Traceable Author Statement more info	PubMed
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP4

Names: ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1; ADP-ribosyltransferase diphtheria toxin-like 4; mVparp; poly [ADP-ribose] polymerase 4; vault poly(ADP-ribose) polymerase

NP_001139450.2

EC 2.4.2.30

XP_036014573.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145978.2 → NP_001139450.2 protein mono-ADP-ribosyltransferase PARP4

Status: VALIDATED

Source sequence(s)

AC154731, AK053992, AK164513, AK172907

Consensus CDS

CCDS49503.1

UniProtKB/Swiss-Prot

E9PYK3, Q6A0B1, Q80UW6, Q8BW82, Q8R3A5

Related

ENSMUSP00000124258.2, ENSMUST00000161553.2

Conserved Domains (7) summary

smart00292
Location:4 → 81

BRCT; breast cancer carboxy-terminal domain

smart00327
Location:870 → 1026

VWA; von Willebrand factor (vWF) type A domain

cd01437
Location:244 → 557

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

TIGR03788
Location:629 → 1174

marine_srt_targ; marine proteobacterial sortase target protein

pfam00644
Location:371 → 559

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam06346
Location:1394 → 1608

Drf_FH1; Formin Homology Region 1

pfam08487
Location:616 → 724

VIT; Vault protein inter-alpha-trypsin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

56812982..56897256

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158680.1 → XP_036014573.1 protein mono-ADP-ribosyltransferase PARP4 isoform X1

Conserved Domains (3) summary

smart00327
Location:167 → 323

VWA; von Willebrand factor (vWF) type A domain

pfam06346
Location:746 → 915

Drf_FH1; Formin Homology Region 1

cl02699
Location:1 → 23

VIT; Vault protein inter-alpha-trypsin domain