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    Ggt-1 gamma-glutamyl transpeptidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ggt-1provided by FlyBase
    Official Full Name
    gamma-glutamyl transpeptidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030932
    Locus tag
    Dmel_CG6461
    See related
    AllianceGenome:FB:FBgn0030932
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6461; Dmel\CG6461; GGT-1
    Summary
    Enables glutathione hydrolase activity. Involved in glutathione metabolic process and response to light stimulus. Located in extracellular space. Is expressed in adult head; embryonic proventriculus; and organism. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ggt-1 in Genome Data Viewer
    Location:
    17C1-17C1; 1-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18505883..18512521, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18399916..18406554, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 2 Neighboring gene Wnt oncogene analog 5 Neighboring gene uncharacterized protein Neighboring gene Histidyl-tRNA synthetase Neighboring gene Beadex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activatable Raman Probes Utilizing Enzyme-Induced Aggregate Formation for Selective Ex Vivo Imaging. Fujioka H, et al. J Am Chem Soc, 2023 Apr 26. PMID 37057960, Free PMC Article
    2. γ-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABAA receptors in Drosophila. Liu J, et al. J Neurochem, 2014 Aug. PMID 24702462
    3. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Yoshikawa S, et al. Nature, 2003 Apr 10. PMID 12660735
    4. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
    5. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamyl transpeptidase
    Names
    CG6461-PA
    CG6461-PB
    Ggt-1-PA
    Ggt-1-PB
    gamma-glutamyl transferase
    NP_001285408.1
    NP_573303.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18505883..18512521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133075.3 → NP_573303.1  gamma-glutamyl transpeptidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TL5, Q9VWT3
      Related
      FBpp0074393
      Conserved Domains (1) summary
      pfam01019
      Location:56 → 566
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. NM_001298479.1 → NP_001285408.1  gamma-glutamyl transpeptidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TL5, Q9VWT3
      Conserved Domains (1) summary
      pfam01019
      Location:56 → 566
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWT3 Q9VWT3

    Gene LinkOut

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