ENGase Endo-beta-N-acetylglucosaminidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ENGaseprovided by FlyBase
Official Full Name: Endo-beta-N-acetylglucosaminidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0030839
Locus tag: Dmel_CG5613
See related: AllianceGenome:FB:FBgn0030839
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5613; Dmel\CG5613
Summary: Enables myosin binding activity. Predicted to be involved in N-glycan processing. Predicted to be located in cytoplasm. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 16A5-16A5; 1-57 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17423591..17428735)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17317624..17322768)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	IEA Inferred from Electronic Annotation more info
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Endo-beta-N-acetylglucosaminidase

Names: CG5613-PA; CG5613-PB; ENGase-PA; ENGase-PB

NP_573215.1

EC 3.2.1.-

EC 3.2.1.96

NP_788923.1

EC 3.2.1.-

EC 3.2.1.96

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17423591..17428735

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132987.2 → NP_573215.1 Endo-beta-N-acetylglucosaminidase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573215.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T8V2, Q9VX51

Related

FBpp0074205

Conserved Domains (1) summary

cd06547
Location:144 → 476

GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
NM_176750.2 → NP_788923.1 Endo-beta-N-acetylglucosaminidase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788923.1

Status: REVIEWED

UniProtKB/TrEMBL

H5V8D6, Q86B46

Related

FBpp0074206

Conserved Domains (1) summary

cd06547
Location:81 → 413

GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...