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    cnp 2',3'-cyclic nucleotide 3' phosphodiesterase [ Danio rerio (zebrafish) ]

    Gene ID: 325896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cnpprovided by ZNC
    Official Full Name
    2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030521-29
    See related
    Ensembl:ENSDARG00000070822 AllianceGenome:ZFIN:ZDB-GENE-030521-29
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cnpl; rich; fd21d08; fi37a10; sb:cb662; wu:fd21d08; wu:fd44a05; wu:fi35d08; wu:fi37a10; si:ch73-158e11.4
    Summary
    Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within axon regeneration. Located in cytosol. Is expressed in several structures, including axis; cardiovascular system; central nervous system; hindbrain neural plate; and neural tube. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cnp in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (17933204..17944295)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (17783397..17794556)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 7 Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene ATP citrate lyase a Neighboring gene uncharacterized LOC137490123

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein. Bandla AC, et al. BMC Neurosci, 2023 Aug 23. PMID 37612637, Free PMC Article
    2. zRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin. Pathi SS, et al. Brain Res, 2012 Sep 20. PMID 22885342, Free PMC Article
    3. Characterization of the domains of zRICH, a protein induced during optic nerve regeneration in zebrafish. Challa M, et al. Brain Res, 2006 Jul 19. PMID 16765331
    4. Cloning and characterization of zRICH, a 2',3'-cyclic-nucleotide 3'-phosphodiesterase induced during zebrafish optic nerve regeneration. Ballestero RP, et al. J Neurochem, 1999 Apr. PMID 10098837
    5. Differential expression and regulation of olig genes in zebrafish. Tiso N, et al. J Comp Neurol, 2009 Jul 20. PMID 19425111

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutant versions of zebrafish RICH proteins were generated to study the roles of the domains of the protein at biochemical and cellular levels.
      Title: Characterization of the domains of zRICH, a protein induced during optic nerve regeneration in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon regeneration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cyclic nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2',3'-cyclic nucleotide 3' phosphodiesterase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase
    Names
    CNPase
    XP_009297613.1
    XP_009297614.1
    XP_009297616.1
    XP_068074924.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      17933204..17944295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299341.4 → XP_009297616.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase

      See identical proteins and their annotated locations for XP_009297616.1

      UniProtKB/TrEMBL
      A0A8M3B0U8, E7FE19
      Conserved Domains (2) summary
      pfam05881
      Location:188 → 402
      CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
      pfam06459
      Location:58 → 136
      RR_TM4-6; Ryanodine Receptor TM 4-6

    2. XM_068218823.1 → XP_068074924.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase

      UniProtKB/TrEMBL
      A0A8M3B0U8, E7FE19

    3. XM_009299338.4 → XP_009297613.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase

      See identical proteins and their annotated locations for XP_009297613.1

      UniProtKB/TrEMBL
      A0A8M3B0U8, E7FE19
      Related
      ENSDARP00000095074.3, ENSDART00000104299.5
      Conserved Domains (2) summary
      pfam05881
      Location:188 → 402
      CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
      pfam06459
      Location:58 → 136
      RR_TM4-6; Ryanodine Receptor TM 4-6

    4. XM_009299339.4 → XP_009297614.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase

      See identical proteins and their annotated locations for XP_009297614.1

      UniProtKB/TrEMBL
      A0A8M3B0U8, E7FE19
      Conserved Domains (2) summary
      pfam05881
      Location:188 → 402
      CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
      pfam06459
      Location:58 → 136
      RR_TM4-6; Ryanodine Receptor TM 4-6
    Nucleotide Protein Strain
    Heading Accession and Version

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