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    vap vacuolar peduncle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vapprovided by FlyBase
    Official Full Name
    vacuolar peduncleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003969
    Locus tag
    Dmel_CG9209
    See related
    AllianceGenome:FB:FBgn0003969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9209; D-RasGAP; Dmel\CG9209; FBpp0073946; p120 RasGAP; p120RasGAP; RAS-GAP; rasGap; RasGap; RasGAP; RasGAP/Vap
    Summary
    Enables GTPase activator activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Involved in several processes, including behavioral response to ethanol; mushroom body development; and negative regulation of signal transduction. Located in cytosol. Is expressed in several structures, including ganglia; hindgut anlage; inclusive hindgut primordium; larval nervous system; and spermatozoon. Used to study alcohol use disorder and neurodegenerative disease. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vap in Genome Data Viewer
    Location:
    14A5-14A6; 1-52 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15999951..16005812, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15893984..15899845, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene extradenticle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mucin 14A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Pamonsinlapatham P, et al. Cell Signal, 2008 Nov. PMID 18761085
    2. Mutants of brain structure and function: what is the significance of the mushroom bodies for behavior? Heisenberg M. Basic Life Sci, 1980. PMID 6779802
    3. Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Cleghon V, et al. Mol Cell, 1998 Dec. PMID 9885560
    4. p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila. Woodcock SA, et al. Biochem J, 2004 Jun 15. PMID 15030317, Free PMC Article
    5. Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins. Gigoux V, et al. J Biol Chem, 2002 Jun 28. PMID 11976319

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fibroblast growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables torso binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of torso signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar peduncle
    Names
    CG9209-PA
    CG9209-PB
    CG9209-PC
    CG9209-PD
    CG9209-PE
    CG9209-PF
    Ras GTPase-activating protein
    p120 Ras GTPase-activating protein
    vacuolar peduncule
    vacuolar pedunculi
    vap-PA
    vap-PB
    vap-PC
    vap-PD
    vap-PE
    vap-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15999951..16005812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298385.1 → NP_001285314.1  vacuolar peduncle, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR23
      Conserved Domains (6) summary
      cd08400
      Location:499 → 622
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:64 → 166
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:252 → 326
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:183 → 241
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd13260
      Location:379 → 484
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      cl02569
      Location:620 → 954
      RasGAP; Ras GTPase Activating Domain

    2. NM_078637.3 → NP_523361.1  vacuolar peduncle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR23
      Related
      FBpp0073945
      Conserved Domains (6) summary
      cd08400
      Location:499 → 622
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:64 → 166
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:252 → 326
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:183 → 241
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd13260
      Location:379 → 484
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      cl02569
      Location:620 → 954
      RasGAP; Ras GTPase Activating Domain

    3. NM_167480.2 → NP_727925.1  vacuolar peduncle, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727925.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR23
      Related
      FBpp0073946
      Conserved Domains (6) summary
      cd08400
      Location:499 → 622
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:64 → 166
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:252 → 326
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:183 → 241
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd13260
      Location:379 → 484
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      cl02569
      Location:620 → 954
      RasGAP; Ras GTPase Activating Domain

    4. NM_206759.2 → NP_996482.1  vacuolar peduncle, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR23
      Conserved Domains (6) summary
      cd08400
      Location:499 → 622
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:64 → 166
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:252 → 326
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:183 → 241
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd13260
      Location:379 → 484
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      cl02569
      Location:620 → 954
      RasGAP; Ras GTPase Activating Domain

    5. NM_167481.3 → NP_727926.2  vacuolar peduncle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727926.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR23
      Related
      FBpp0089147
      Conserved Domains (6) summary
      cd08400
      Location:499 → 622
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:64 → 166
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:252 → 326
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:183 → 241
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd13260
      Location:379 → 484
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      cl02569
      Location:620 → 954
      RasGAP; Ras GTPase Activating Domain

    6. NM_001298386.1 → NP_001285315.1  vacuolar peduncle, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR23
      Conserved Domains (6) summary
      cd08400
      Location:499 → 622
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:64 → 166
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:252 → 326
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:183 → 241
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd13260
      Location:379 → 484
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      cl02569
      Location:620 → 954
      RasGAP; Ras GTPase Activating Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR23 Q8IR23
    Q8T9B1 Q8T9B1

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