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    Flo2 Flotillin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32425, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Flo2provided by FlyBase
    Official Full Name
    Flotillin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0264078
    Locus tag
    Dmel_CG32593
    See related
    AllianceGenome:FB:FBgn0264078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11547; CG14409; CG32593; Dmel\CG32593; DmFlo2; Flo; Flo-2; flo2; FLO2; FLO[Dm]-2; mdcds_54791; reggie-1
    Summary
    Predicted to enable protease binding activity. Involved in melanotic encapsulation of foreign target and positive regulation of filopodium assembly. Located in cytosol and plasma membrane. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; ganglia; and optic chiasma. Orthologous to human FLOT2 (flotillin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Flo2 in Genome Data Viewer
    Location:
    12F5-13A1; 1-49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14839376..14933946)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14733409..14827979)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutaredoxin 5 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46391 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fezzik Neighboring gene uncharacterized protein Neighboring gene Ecdysone oxidase Neighboring gene uncharacterized protein Neighboring gene pudgy Neighboring gene long non-coding RNA:CR44831 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster. Galbiati F, et al. Gene, 1998 Apr 14. PMID 9573373
    2. Microinjection wound assay and in vivo localization of epidermal wound response reporters in Drosophila embryos. Juarez MT, et al. J Vis Exp, 2013 Nov 1. PMID 24300796, Free PMC Article
    3. Acute exposure of Nicotine during Drosophila puncture injury activates an epidermal wound response reaction. Cherenfant C, et al. MicroPubl Biol, 2021. PMID 34235406, Free PMC Article
    4. Selective sweep in the Flotillin-2 region of European Drosophila melanogaster. Werzner A, et al. PLoS One, 2013. PMID 23437190, Free PMC Article
    5. Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production. Wu CY, et al. iScience, 2021 Dec 17. PMID 34877496, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flotillin-2 and constitutively active Src42A are also sufficient, when overexpressed at high levels, to inhibit wound-induced transcription in epidermal cells.
      Title: Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of myoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    part_of flotillin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of flotillin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    flotillin 2
    Names
    CG32593-PA
    CG32593-PB
    CG32593-PD
    CG32593-PE
    CG32593-PF
    CG32593-PG
    CG32593-PH
    CG32593-PI
    CG32593-PJ
    CG32593-PK
    CG32593-PL
    CG32593-PM
    Flo2-PA
    Flo2-PB
    Flo2-PD
    Flo2-PE
    Flo2-PF
    Flo2-PG
    Flo2-PH
    Flo2-PI
    Flo2-PJ
    Flo2-PK
    Flo2-PL
    Flo2-PM
    Flotillin-2
    flotillin
    flotillin2
    flottilin 2
    reggie-1
    reggie1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14839376..14933946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272624.2 → NP_001259553.1  flotillin 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHL7
      Conserved Domains (2) summary
      COG2268
      Location:8 → 440
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 201
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. NM_167416.3 → NP_727798.1  flotillin 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727798.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61492, Q0KHS9, Q8SZW0, Q9I7S0, Q9VXZ9
      UniProtKB/TrEMBL
      F2FB46
      Related
      FBpp0073768
      Conserved Domains (2) summary
      COG2268
      Location:8 → 430
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 191
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    3. NM_167417.3 → NP_727799.1  flotillin 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4F2
      Related
      FBpp0073769
      Conserved Domains (2) summary
      COG2268
      Location:8 → 417
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    4. NM_167415.3 → NP_727797.1  flotillin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61492, Q0KHS9, Q8SZW0, Q9I7S0, Q9VXZ9
      UniProtKB/TrEMBL
      F2FB46
      Related
      FBpp0073766
      Conserved Domains (2) summary
      COG2268
      Location:8 → 430
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 191
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    5. NM_001272625.2 → NP_001259554.1  flotillin 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJN2
      Conserved Domains (3) summary
      COG2268
      Location:8 → 429
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam15975
      Location:314 → 387
      Flot; Flotillin

    6. NM_078602.4 → NP_511157.2  flotillin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511157.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4F2
      Related
      FBpp0073767
      Conserved Domains (2) summary
      COG2268
      Location:8 → 417
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    7. NM_001272623.2 → NP_001259552.1  flotillin 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHT0
      Conserved Domains (2) summary
      COG2268
      Location:8 → 427
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 188
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    8. NM_001272626.2 → NP_001259555.1  flotillin 2, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61492, Q0KHS9, Q8SZW0, Q9I7S0, Q9VXZ9
      UniProtKB/TrEMBL
      F2FB46
      Conserved Domains (2) summary
      COG2268
      Location:8 → 430
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34 → 191
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    9. NM_167419.2 → NP_727812.2  flotillin 2, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61492
      Conserved Domains (3) summary
      smart00244
      Location:18 → 189
      PHB; prohibitin homologues
      cd03399
      Location:12 → 109
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam15975
      Location:245 → 318
      Flot; Flotillin

    10. NM_001169287.2 → NP_001162758.1  flotillin 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJL2
      Conserved Domains (3) summary
      COG2268
      Location:30 → 332
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:21 → 93
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam15975
      Location:229 → 302
      Flot; Flotillin

    11. NM_167421.2 → NP_727814.1  flotillin 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP31
      Related
      FBpp0073771
      Conserved Domains (1) summary
      COG2268
      Location:1 → 273
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

    12. NM_001169288.1 → NP_001162759.1  flotillin 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP31
      Conserved Domains (1) summary
      COG2268
      Location:1 → 273
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V4F2 A4V4F2
    C9QP31 C9QP31
    E1JJL2 E1JJL2
    F2FB46 F2FB46
    M9PHL7 M9PHL7
    M9PHT0 M9PHT0
    M9PJN2 M9PJN2
    O61492.3 O61492

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