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    tomm40 translocase of outer mitochondrial membrane 40 homolog (yeast) [ Danio rerio (zebrafish) ]

    Gene ID: 322645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tomm40provided by ZNC
    Official Full Name
    translocase of outer mitochondrial membrane 40 homolog (yeast)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1365
    See related
    Ensembl:ENSDARG00000092112 AllianceGenome:ZFIN:ZDB-GENE-030131-1365
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64168; wu:fb68h07
    Summary
    Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within protein transport and transmembrane transport. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tomm40 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (25673104..25680713, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (25758075..25765666, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 2a Neighboring gene derlin 1 Neighboring gene NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 61 Neighboring gene BCL3 transcription coactivator Neighboring gene uncharacterized LOC137487904

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Endothelial Mitochondrial Preprotein Translocase Tomm7-Rac1 Signaling Axis Dominates Cerebrovascular Network Homeostasis. Shi D, et al. Arterioscler Thromb Vasc Biol, 2018 Nov. PMID 30354240
    2. Structural Analysis and Spatiotemporal Expression of Atxn1 Genes in Zebrafish Embryos and Larvae. Vauti F, et al. Int J Mol Sci, 2021 Oct 21. PMID 34768779, Free PMC Article
    3. Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish. Uszczynska-Ratajczak B, et al. Life Sci Alliance, 2023 Jan. PMID 36283702, Free PMC Article
    4. Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Garcia-Reyero N, et al. Bull Environ Contam Toxicol, 2016 Jun. PMID 27086301, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM40 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199614.1 → NP_955908.1  mitochondrial import receptor subunit TOM40 homolog

      See identical proteins and their annotated locations for NP_955908.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053295
      UniProtKB/TrEMBL
      A0A8M2B4D6, Q7T314
      Related
      ENSDARP00000003894.5, ENSDART00000015302.7
      Conserved Domains (1) summary
      cd07305
      Location:60 → 344
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      25673104..25680713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351318.3 → XP_017206807.1  mitochondrial import receptor subunit TOM40 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1R1

    2. XM_005158091.5 → XP_005158148.1  mitochondrial import receptor subunit TOM40 homolog isoform X2

      See identical proteins and their annotated locations for XP_005158148.1

      UniProtKB/TrEMBL
      A0A8M2B4D6, Q7T314
      Conserved Domains (1) summary
      cd07305
      Location:60 → 344
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
    Nucleotide Protein Strain
    Heading Accession and Version

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