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    Atp8b5 ATPase, class I, type 8B, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 320571, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp8b5provided by MGI
    Official Full Name
    ATPase, class I, type 8B, member 5provided by MGI
    Primary source
    MGI:MGI:2444287
    See related
    Ensembl:ENSMUSG00000028457 AllianceGenome:MGI:2444287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Feta; 4930417M19Rik
    Summary
    Enables phosphatidylcholine flippase activity and phosphatidylethanolamine flippase activity. Involved in Golgi organization and phospholipid transport. Located in acrosomal vesicle and membrane. Orthologous to human ATP8B5P (ATPase phospholipid transporting 8B5, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 10.1) and mammary gland adult (RPKM 0.4) See more
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    Genomic context

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    See Atp8b5 in Genome Data Viewer
    Location:
    4 A5; 4 23.01 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43266716..43373831)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43266722..43373831)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene unc-13 homolog B Neighboring gene predicted gene, 23709 Neighboring gene predicted gene, 25010 Neighboring gene STARR-seq mESC enhancer starr_10048 Neighboring gene STARR-seq mESC enhancer starr_10049 Neighboring gene predicted gene, 46851 Neighboring gene STARR-seq mESC enhancer starr_10051 Neighboring gene predicted gene, 46850 Neighboring gene STARR-seq mESC enhancer starr_10053 Neighboring gene RUN and SH3 domain containing 2 Neighboring gene predicted gene, 52698 Neighboring gene ciliary microtubule inner protein 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesis. Xu P, et al. J Cell Sci, 2009 Aug 15. PMID 19657017
    2. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. Suzuki A, et al. J Reprod Immunol, 2024 Jun. PMID 38697008,
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylethanolamine flippase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase FetA
    Names
    ATPase class I type 8B member 2-like protein
    flippase expressed in testis A
    probable phospholipid-transporting ATPase FetA
    testis flippase
    NP_796169.2
    XP_006538058.1
    XP_006538059.1
    XP_006538060.1
    XP_006538061.1
    XP_006538062.1
    XP_006538064.1
    XP_006538065.1
    XP_006538066.1
    XP_030109467.1
    XP_030109468.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177195.3 → NP_796169.2  phospholipid-transporting ATPase FetA

      See identical proteins and their annotated locations for NP_796169.2

      Status: VALIDATED

      Source sequence(s)
      AL732504
      Consensus CDS
      CCDS18091.2
      UniProtKB/Swiss-Prot
      A2AIL8, A3FIN4, Q8BVE9, Q8BVS7
      Related
      ENSMUSP00000103575.3, ENSMUST00000107942.9
      Conserved Domains (6) summary
      TIGR01652
      Location:52 → 1123
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:108 → 334
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:496 → 591
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38 → 103
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:865 → 1117
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:833 → 854
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43266716..43373831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537995.5 → XP_006538058.1  phospholipid-transporting ATPase FetA isoform X1

      Conserved Domains (1) summary
      cd02073
      Location:54 → 1008
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. XM_006537998.5 → XP_006538061.1  phospholipid-transporting ATPase FetA isoform X4

      Conserved Domains (1) summary
      cd02073
      Location:54 → 945
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    3. XM_006537997.5 → XP_006538060.1  phospholipid-transporting ATPase FetA isoform X3

      Conserved Domains (1) summary
      cd02073
      Location:54 → 953
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    4. XM_006538003.5 → XP_006538066.1  phospholipid-transporting ATPase FetA isoform X9

      Conserved Domains (1) summary
      cd02073
      Location:1 → 633
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    5. XM_030253607.2 → XP_030109467.1  phospholipid-transporting ATPase FetA isoform X6

      Conserved Domains (1) summary
      cd02073
      Location:9 → 913
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    6. XM_030253608.2 → XP_030109468.1  phospholipid-transporting ATPase FetA isoform X9

      Conserved Domains (1) summary
      cd02073
      Location:1 → 633
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    7. XM_006538002.5 → XP_006538065.1  phospholipid-transporting ATPase FetA isoform X8

      Conserved Domains (1) summary
      cd02073
      Location:9 → 880
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    8. XM_006538001.5 → XP_006538064.1  phospholipid-transporting ATPase FetA isoform X7

      Conserved Domains (1) summary
      cd02073
      Location:54 → 886
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    9. XM_006537996.3 → XP_006538059.1  phospholipid-transporting ATPase FetA isoform X2

      Conserved Domains (1) summary
      cd02073
      Location:9 → 963
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    10. XM_006537999.3 → XP_006538062.1  phospholipid-transporting ATPase FetA isoform X5

      Conserved Domains (1) summary
      cd02073
      Location:9 → 925
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RNA

    1. XR_003954967.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3FIN4.1 GenPept UniProtKB/Swiss-Prot:A3FIN4

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