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    Cfp1 CXXC finger protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfp1provided by FlyBase
    Official Full Name
    CXXC finger protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030121
    Locus tag
    Dmel_CG17446
    See related
    AllianceGenome:FB:FBgn0030121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17446; CXXC1; dCfp1; dCXXC1; Dmel\CG17446
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Part of Set1C/COMPASS complex. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cfp1 in Genome Data Viewer
    Location:
    8D4-8D4; 1-27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9270434..9272960, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9164467..9166993, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Extracellularly regulated kinase 7 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene aladin Neighboring gene c11.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Signatures of Drug Response Variability in Drosophila melanogaster. Rohde PD, et al. Genetics, 2019 Oct. PMID 31455722, Free PMC Article
    2. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article
    3. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article
    4. COMPASS and SWI/SNF complexes in development and disease. Cenik BK, et al. Nat Rev Genet, 2021 Jan. PMID 32958894
    5. Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. Ardehali MB, et al. EMBO J, 2011 Jun 21. PMID 21694722, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CXXC finger protein 1
    Names
    CG17446-PA
    CG17446-PB
    Cfp1-PA
    Cfp1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9270434..9272960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201641.2 → NP_001188570.1  CXXC finger protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS35
      Conserved Domains (3) summary
      pfam02008
      Location:158 → 198
      zf-CXXC; CXXC zinc finger domain
      cd15553
      Location:42 → 87
      PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
      pfam12269
      Location:280 → 512
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    2. NM_132328.3 → NP_572556.1  CXXC finger protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572556.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W352
      Related
      FBpp0071262
      Conserved Domains (3) summary
      pfam02008
      Location:178 → 218
      zf-CXXC; CXXC zinc finger domain
      cd15553
      Location:62 → 107
      PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
      pfam12269
      Location:300 → 532
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MS35 M9MS35
    Q9W352.1 Q9W352

    Gene LinkOut

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