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    CG2258 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2258provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029997
    Locus tag
    Dmel_CG2258
    See related
    AllianceGenome:FB:FBgn0029997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2258
    Summary
    Enables myosin binding activity. Predicted to be involved in endocytosis. Is expressed in adult head and organism. Orthologous to human NCKIPSD (NCK interacting protein with SH3 domain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2258 in Genome Data Viewer
    Location:
    7D6-7D6; 1-22 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8094250..8102095, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7988283..7996128, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45535 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin conjugating enzyme E2H Neighboring gene Glutamate-cysteine ligase catalytic subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Readapting to DCV Infection without Wolbachia: Frequency Changes of Drosophila Antiviral Alleles Can Replace Endosymbiont Protection. Faria VG, et al. Genome Biol Evol, 2018 Jul 1. PMID 29947761, Free PMC Article
    2. Drosophila suzukii: the genetic footprint of a recent, worldwide invasion. Adrion JR, et al. Mol Biol Evol, 2014 Dec. PMID 25158796, Free PMC Article
    3. Genome-Wide Association Analysis of Anoxia Tolerance in Drosophila melanogaster. Campbell JB, et al. G3 (Bethesda), 2019 Sep 4. PMID 31311780, Free PMC Article
    4. Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos. Liu R, et al. Development, 2008 Jan. PMID 18045836
    5. Endogenously imprinted genes in Drosophila melanogaster. McEachern LA, et al. Mol Genet Genomics, 2014 Aug. PMID 24658702

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2258-PA
    CG2258-PB
    CG2258-PC
    CG2258-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8094250..8102095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298071.1 → NP_001285000.1  uncharacterized protein Dmel_CG2258, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3K6
      Conserved Domains (3) summary
      PHA03420
      Location:108 → 188
      PHA03420; E4 protein; Provisional
      cd11849
      Location:1 → 55
      SH3_SPIN90; Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
      pfam09431
      Location:631 → 766
      DUF2013; Protein of unknown function (DUF2013)

    2. NM_206649.2 → NP_996372.1  uncharacterized protein Dmel_CG2258, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3K6
      Conserved Domains (3) summary
      PHA03420
      Location:108 → 188
      PHA03420; E4 protein; Provisional
      cd11849
      Location:1 → 55
      SH3_SPIN90; Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
      pfam09431
      Location:631 → 766
      DUF2013; Protein of unknown function (DUF2013)

    3. NM_206648.2 → NP_996371.1  uncharacterized protein Dmel_CG2258, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3K6
      Conserved Domains (3) summary
      PHA03420
      Location:108 → 188
      PHA03420; E4 protein; Provisional
      cd11849
      Location:1 → 55
      SH3_SPIN90; Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
      pfam09431
      Location:631 → 766
      DUF2013; Protein of unknown function (DUF2013)

    4. NM_132211.2 → NP_572439.1  uncharacterized protein Dmel_CG2258, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3K6
      Related
      FBpp0071064
      Conserved Domains (3) summary
      PHA03420
      Location:108 → 188
      PHA03420; E4 protein; Provisional
      cd11849
      Location:1 → 55
      SH3_SPIN90; Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
      pfam09431
      Location:631 → 766
      DUF2013; Protein of unknown function (DUF2013)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3K6 Q9W3K6

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