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    CG1571 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31725, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1571provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029993
    Locus tag
    Dmel_CG1571
    See related
    AllianceGenome:FB:FBgn0029993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1571
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be part of outer dynein arm. Is expressed in spermatogonium and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1571 in Genome Data Viewer
    Location:
    7D5-7D5; 1-22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8075877..8078240)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7969910..7972273)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene myospheroid Neighboring gene Upf2 Neighboring gene Lipid droplet subset dehydrogenase 1 Neighboring gene antisense RNA:CR45535 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article
    2. Dyneins across eukaryotes: a comparative genomic analysis. Wickstead B, et al. Traffic, 2007 Dec. PMID 17897317, Free PMC Article
    3. The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains. Santana JF, et al. Cell Rep, 2020 Mar 10. PMID 32160531, Free PMC Article
    4. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of outer dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1571-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8075877..8078240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132207.3 → NP_572435.1  uncharacterized protein Dmel_CG1571 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MTB1, Q9W3L0
      Related
      FBpp0071062
      Conserved Domains (3) summary
      COG2319
      Location:211 → 488
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:229 → 269
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:210 → 462
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MTB1 Q8MTB1
    Q9W3L0 Q9W3L0

    Gene LinkOut

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