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Cd2ap CD2-associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 316258, updated on 9-Dec-2024

Summary

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Official Symbol: Cd2approvided by RGD
Official Full Name: CD2-associated proteinprovided by RGD
Primary source: RGD:727803
See related: EnsemblRapid:ENSRNOG00000011987 AllianceGenome:RGD:727803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CMS
Summary: Enables beta-catenin binding activity; cadherin binding activity; and vascular endothelial growth factor receptor binding activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of receptor-mediated endocytosis; and vesicle organization. Located in cell leading edge; endocytic vesicle; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 3. Orthologous to human CD2AP (CD2 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 468.4), Kidney (RPKM 448.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Cd2ap in Genome Data Viewer

Location:: 9q13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (25580071..25679968)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (18086744..18182744)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (20794680..20858438)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis.
Title: Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis.
CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting
Title: The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity.
There might be a potential signaling pathway between PAX2 and CD2AP in RIF disease. Further research is needed to determine the association in RIF disease.
Title: The potential signal pathway between PAX2 and CD2AP in the renal interstitial fibrosis disease.
findings show that the filament-forming GTPase septin 7 is expressed in podocytes and associates with CD2-associated protein (CD2AP) and nephrin, both essential for glomerular ultrafiltration
Title: Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.
Dual labeled immunofluorescence showed ephrin-B1 colocalized with the slit diaphragm proteins nephrin and CD2-associated protein.
Title: Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte.
It is concluded that CD2AP interacts with E-cadherin and co-localizes with F-actin in the leading edge of migrating cells, and significantly contributes to cell migration in restituting gastric epithelium.
Title: CD2AP contributes to cell migration and adhesion in cultured gastric epithelium.
CD2AP may be related to cell repair and/or cell differentiation following ischemia reperfusion injury.
Title: CD2AP expression in a renal ischemia/reperfusion injury model and analysis of its related genes using overexpression and RNA interference technique.
TGF-beta3 selectively disrupts Sertoli-germ cell adhesion in the seminiferous epithelium to facilitate germ cell migration without compromising BTB when TbetaRI interacts only with adaptor CD2AP
Title: Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion.
the c-Cbl/CD2AP complex binds to activated Flt-1 and plays a crucial role in its endocytosis and subsequent degradation.
Title: The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rab protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in collateral sprouting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in endothelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelium development	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in immunological synapse formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in localization of cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within localization of cell	ISO Inferred from Sequence Orthology more info
involved_in lymph node development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymph node development	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood-brain barrier	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in membrane organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small GTPase mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta1 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta1 production	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotrophin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein heterooligomerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein heterooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in renal albumin absorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal albumin absorption	ISO Inferred from Sequence Orthology more info
involved_in response to glial cell derived neurotrophic factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glial cell derived neurotrophic factor	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to transforming growth factor beta	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to transforming growth factor beta	ISO Inferred from Sequence Orthology more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta1 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of transforming growth factor beta1 production	ISO Inferred from Sequence Orthology more info
involved_in vesicle organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cell leading edge	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
is_active_in growth cone	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
is_active_in late endosome	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope lumen	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info
is_active_in podosome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in slit diaphragm	IEA Inferred from Electronic Annotation more info
is_active_in slit diaphragm	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD2-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181475.3 → NP_852140.2 CD2-associated protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

F1LRS8, Q7TSS5

UniProtKB/TrEMBL

A0A8L2Q7T7, A6JJ47

Related

ENSRNOP00000088324.2, ENSRNOT00000120136.2

Conserved Domains (3) summary

cd12053
Location:3 → 58

SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein

cd12054
Location:111 → 165

SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein

cd12056
Location:271 → 327

SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

25580071..25679968

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083538.2 → XP_038939466.1 CD2-associated protein isoform X1

UniProtKB/TrEMBL

A0A8I6A6A6

Conserved Domains (3) summary

cd12053
Location:3 → 58

SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein

cd12054
Location:111 → 165

SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein

cd12056
Location:271 → 327

SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein
XM_039083541.2 → XP_038939469.1 CD2-associated protein isoform X3

Conserved Domains (3) summary

cd12053
Location:3 → 58

SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein

cd12054
Location:111 → 165

SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein

cd12056
Location:271 → 327

SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein
XM_039083539.2 → XP_038939467.1 CD2-associated protein isoform X2

UniProtKB/TrEMBL

A0A8L2Q7T7, A6JJ48

Related

ENSRNOP00000016291.5, ENSRNOT00000016291.5

Conserved Domains (2) summary

cd12054
Location:64 → 118

SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein

cd12056
Location:224 → 280

SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein
XM_039083540.2 → XP_038939468.1 CD2-associated protein isoform X2

UniProtKB/TrEMBL

A0A8L2Q7T7, A6JJ48

Related

ENSRNOP00000103834.1, ENSRNOT00000142796.1

Conserved Domains (2) summary

cd12054
Location:64 → 118

SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein

cd12056
Location:224 → 280

SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein