Pink1 PTEN-induced putative kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pink1provided by FlyBase
Official Full Name: PTEN-induced putative kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0029891
Locus tag: Dmel_CG4523
See related: AllianceGenome:FB:FBgn0029891
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:GH23468; CG4523; Dmel\CG4523; dpink; dPink1; dPINk1; dPINK1; Pink; PINK-1; pink1; PINK1
Summary: Enables ATP-dependent protein binding activity and protein serine/threonine kinase activity. Involved in several processes, including memory; mitochondrion organization; and regulation of mitochondrion organization. Located in Nebenkern; cytosol; and mitochondrion. Is active in mitochondrial outer membrane. Is expressed in organism. Used to study Hirschsprung's disease; Parkinson's disease; Parkinson's disease 6; early-onset Parkinson's disease; and testicular cancer. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 6C6-6C6; 1-18 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6683798..6687302)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6577831..6581335)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PINK1 and Parkin rescue motor defects and mitochondria dysfunction induced by a patient-derived HSPB3 mutant in Drosophila models.
Title: PINK1 and Parkin rescue motor defects and mitochondria dysfunction induced by a patient-derived HSPB3 mutant in Drosophila models.
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Title: PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Drosophila ZIP13 over-expression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria.
Title: Drosophila ZIP13 over-expression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria.
Differential mitochondrial roles for alpha-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.
Title: Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.
Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.
Title: Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.
Overexpressed PERK suppresses the neurodegenerative phenotypes in PINK1(B9) flies by enhancing mitochondrial function.
Title: Overexpressed PERK suppresses the neurodegenerative phenotypes in PINK1(B9) flies by enhancing mitochondrial function.
Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease.
Title: Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease.
The dysregulated Pink1(-) Drosophila mitochondrial proteome is partially corrected with exercise.
Title: The dysregulated Pink1(-) Drosophila mitochondrial proteome is partially corrected with exercise.
Knockout of PINK1 altered the neural connectivity of Drosophila dopamine PPM3 neurons at input and output sites.
Title: Knockout of PINK1 altered the neural connectivity of Drosophila dopamine PPM3 neurons at input and output sites.
TDP-43 and PINK1 mediate CHCHD10(S59L) mutation-induced defects in Drosophila and in vitro.
Title: TDP-43 and PINK1 mediate CHCHD10(S59L) mutation-induced defects in Drosophila and in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular distribution of mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy of mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial electron transport, NADH to ubiquinone	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Nebenkern	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PTEN-induced putative kinase 1

Names: CG4523-PA; CG4523-PB; CG4523-PC; CG4523-PD; CG4523-PE; CG4523-PF; CG4523-PG; CG4523-PH; CG4523-PI; PINK1; PTEN induced putative kinase 1; PTEN-induced kinase 1; Pink1-PA; Pink1-PB; Pink1-PC; Pink1-PD; Pink1-PE; Pink1-PF; Pink1-PG; Pink1-PH; Pink1-PI; Pten-induced kinase 1(PINK1); ortholog of PINK1; phosphatase and tensin homolog-induced putative kinase 1; pink

NP_001027049.1

EC 2.7.11.1

NP_001027050.1

EC 2.7.11.1

NP_001027051.1

EC 2.7.11.1

NP_001027052.1

EC 2.7.11.1

NP_001027053.1

EC 2.7.11.1

NP_001027054.1

EC 2.7.11.1

NP_001284952.1

EC 2.7.11.1

NP_572340.2

EC 2.7.11.1

NP_727110.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6683798..6687302

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001031878.2 → NP_001027049.1 PTEN-induced putative kinase 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027049.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_001031880.3 → NP_001027051.1 PTEN-induced putative kinase 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027051.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_001031879.3 → NP_001027050.1 PTEN-induced putative kinase 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027050.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_001031881.3 → NP_001027052.1 PTEN-induced putative kinase 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027052.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_001031883.3 → NP_001027054.1 PTEN-induced putative kinase 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027054.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_132112.5 → NP_572340.2 PTEN-induced putative kinase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572340.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Related

FBpp0070917

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_167083.4 → NP_727110.1 PTEN-induced putative kinase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727110.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Related

FBpp0070918

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_001031882.3 → NP_001027053.1 PTEN-induced putative kinase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027053.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
NM_001298023.1 → NP_001284952.1 PTEN-induced putative kinase 1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284952.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHV6, Q961J3

Conserved Domains (1) summary

cd14018
Location:328 → 639

STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1