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    Pou2af3 POU class 2 homeobox associating factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pou2af3provided by RGD
    Official Full Name
    POU class 2 homeobox associating factor 3provided by RGD
    Primary source
    RGD:1563866
    See related
    EnsemblRapid:ENSRNOG00000042165 AllianceGenome:RGD:1563866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Colca2; RGD1563866
    Summary
    Predicted to enable DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Orthologous to human POU2AF3 (POU class 2 homeobox associating factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 12.6), Lung (RPKM 11.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pou2af3 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60484596..60493475, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51588237..51597114, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55674561..55682811, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RGD1562811 Neighboring gene POU class 2 homeobox associating factor 1 Neighboring gene uncharacterized LOC103693092 Neighboring gene POU class 2 homeobox associating factor 2 Neighboring gene uncharacterized LOC120094149

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Peltekova VD, et al. Int J Cancer, 2014 May 15. PMID 24154973, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables POU domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    POU class 2 homeobox associating factor 3
    Names
    colorectal cancer associated 2
    colorectal cancer-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399310.1 → NP_001386239.1  POU class 2 homeobox associating factor 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6G7E3
      Related
      ENSRNOP00000102785.1, ENSRNOT00000148053.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      60484596..60493475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082367.2 → XP_038938295.1  POU class 2 homeobox associating factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G7E3

    2. XM_017596029.3 → XP_017451518.1  POU class 2 homeobox associating factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G7E3, D4A677
      Related
      ENSRNOP00000061856.4, ENSRNOT00000065744.5

    3. XM_039082365.2 → XP_038938293.1  POU class 2 homeobox associating factor 3 isoform X2

      UniProtKB/TrEMBL
      A6J4H3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.