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    Deup1 deuterosome assembly protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Deup1provided by RGD
    Official Full Name
    deuterosome assembly protein 1provided by RGD
    Primary source
    RGD:1306632
    See related
    EnsemblRapid:ENSRNOG00000061247 AllianceGenome:RGD:1306632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc67; RGD1306632
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in centriole and deuterosome. Orthologous to human DEUP1 (deuterosome assembly protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 254.2) and Lung (RPKM 15.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Deup1 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (20661687..20724083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (12380300..12442649, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (14094742..14157232, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene V-type proton ATPase subunit G 1 pseudogene Neighboring gene uncharacterized LOC134479995 Neighboring gene single-pass membrane protein with coiled-coil domains 4 Neighboring gene uncharacterized LOC134479996 Neighboring gene solute carrier family 36 member 4 Neighboring gene melatonin receptor 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in multi-ciliated epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multi-ciliated epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in deuterosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in deuterosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in deuterosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in deuterosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    deuterosome assembly protein 1
    Names
    coiled-coil domain containing 67
    coiled-coil domain-containing protein 67
    deuterosome protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014087.1 → NP_001014109.2  deuterosome assembly protein 1

      See identical proteins and their annotated locations for NP_001014109.2

      Status: VALIDATED

      Source sequence(s)
      BC085333
      UniProtKB/Swiss-Prot
      Q5U3Z6
      UniProtKB/TrEMBL
      A0A8L2R0S4
      Related
      ENSRNOP00000108386.1, ENSRNOT00000173158.1
      Conserved Domains (1) summary
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      20661687..20724083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265331.1 → XP_063121401.1  deuterosome assembly protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2R0S4

    2. XM_008765933.4 → XP_008764155.1  deuterosome assembly protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008764155.1

      UniProtKB/TrEMBL
      A0A8L2R0S4, A0A8L2R4Y5
      Conserved Domains (2) summary
      COG1196
      Location:140 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    3. XM_063265330.1 → XP_063121400.1  deuterosome assembly protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5U3Z6
      UniProtKB/TrEMBL
      A0A8L2R0S4

    4. XM_039081354.2 → XP_038937282.1  deuterosome assembly protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2R0S4
      Related
      ENSRNOP00000090446.1, ENSRNOT00000110026.2
      Conserved Domains (2) summary
      COG1196
      Location:123 → 437
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    5. XM_039081353.2 → XP_038937281.1  deuterosome assembly protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R0S4, A0A8L2R4Y5
      Related
      ENSRNOP00000072022.2, ENSRNOT00000089364.3
      Conserved Domains (2) summary
      COG1196
      Location:140 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    6. XM_008765935.4 → XP_008764157.1  deuterosome assembly protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R0S4
      Conserved Domains (1) summary
      pfam17045
      Location:1 → 258
      CEP63; Centrosomal protein of 63 kDa

    7. XM_063265332.1 → XP_063121402.1  deuterosome assembly protein 1 isoform X6

    8. XM_039081355.2 → XP_038937283.1  deuterosome assembly protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8L2R0S4
      Conserved Domains (2) summary
      COG1196
      Location:140 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    9. XM_039081356.2 → XP_038937284.1  deuterosome assembly protein 1 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:140 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    10. XM_039081359.2 → XP_038937287.1  deuterosome assembly protein 1 isoform X9

      Conserved Domains (2) summary
      COG1196
      Location:226 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    11. XM_063265333.1 → XP_063121403.1  deuterosome assembly protein 1 isoform X7

    12. XM_063265335.1 → XP_063121405.1  deuterosome assembly protein 1 isoform X8

    13. XM_039081358.2 → XP_038937286.1  deuterosome assembly protein 1 isoform X8

      Conserved Domains (2) summary
      COG1196
      Location:140 → 428
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa

    14. XM_039081360.2 → XP_038937288.1  deuterosome assembly protein 1 isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:226 → 425
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:12 → 279
      CEP63; Centrosomal protein of 63 kDa
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U3Z6.2 GenPept UniProtKB/Swiss-Prot:Q5U3Z6

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