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    Card10 caspase recruitment domain family, member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315120, updated on 9-Dec-2024

    Summary

    Official Symbol
    Card10provided by RGD
    Official Full Name
    caspase recruitment domain family, member 10provided by RGD
    Primary source
    RGD:1304949
    See related
    EnsemblRapid:ENSRNOG00000008401 AllianceGenome:RGD:1304949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including activation of NF-kappaB-inducing kinase activity; negative regulation of cell migration involved in sprouting angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in immunological synapse. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD10 (caspase recruitment domain family member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.0), Lung (RPKM 64.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Card10 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112210944..112252044, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110330460..110371551, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119998639..120028632, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549375 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 2 Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene CDC42 effector protein 1 Neighboring gene uncharacterized LOC134479608 Neighboring gene galectin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in immunological synapse  

    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130554.1NP_001124026.1  caspase recruitment domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_001124026.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HSM0, D4A425
      Conserved Domains (3) summary
      COG1196
      Location:147450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:27112
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:696761
      SH3; Src Homology 3 domain superfamily
    2. NM_001434610.1NP_001421539.1  caspase recruitment domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSM0, D4A425
    3. NM_001434611.1NP_001421540.1  caspase recruitment domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4A425

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112210944..112252044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079260.2XP_038935188.1  caspase recruitment domain-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      D4A425
      Conserved Domains (3) summary
      COG1196
      Location:147450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:27112
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:735800
      SH3; Src Homology 3 domain superfamily
    2. XM_063263609.1XP_063119679.1  caspase recruitment domain-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      D4A425
    3. XM_063263610.1XP_063119680.1  caspase recruitment domain-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      D4A425
    4. XM_039079258.2XP_038935186.1  caspase recruitment domain-containing protein 10 isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:196499
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:76161
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:784849
      SH3; Src Homology 3 domain superfamily
    5. XM_039079257.2XP_038935185.1  caspase recruitment domain-containing protein 10 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:196499
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:76161
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:784849
      SH3; Src Homology 3 domain superfamily
    6. XM_063263608.1XP_063119678.1  caspase recruitment domain-containing protein 10 isoform X3

      Related
      ENSRNOP00000011215.6, ENSRNOT00000011215.8
    7. XM_039079261.2XP_038935189.1  caspase recruitment domain-containing protein 10 isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:196499
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:76161
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
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