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    PGAP1 Post-GPI attachment to proteins 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGAP1provided by FlyBase
    Official Full Name
    Post-GPI attachment to proteins 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029789
    Locus tag
    Dmel_CG3160
    See related
    AllianceGenome:FB:FBgn0029789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3160; Dmel\CG3160
    Summary
    Predicted to enable phosphatidylinositol deacylase activity. Predicted to be involved in GPI anchor biosynthetic process and positive regulation of ER to Golgi vesicle-mediated transport. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Orthologous to human PGAP1 (post-GPI attachment to proteins inositol deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PGAP1 in Genome Data Viewer
    Location:
    5A12-5A13; 1-12 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5685253..5689473, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5579286..5583506, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44958 Neighboring gene Gustatory receptor 5a Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45525 Neighboring gene crossveinless Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila suzukii: the genetic footprint of a recent, worldwide invasion. Adrion JR, et al. Mol Biol Evol, 2014 Dec. PMID 25158796, Free PMC Article
    2. Female site-specific transposase-induced recombination: a high-efficiency method for fine mapping mutations on the X chromosome in Drosophila. Marcus JM. Genetics, 2003 Feb. PMID 12618398, Free PMC Article
    3. crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling. Vilmos P, et al. EMBO Rep, 2005 Mar. PMID 15711536, Free PMC Article
    4. The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Shimmi O, et al. Dev Biol, 2005 Jun 1. PMID 15936330
    5. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol deacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol deacylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ER to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Post-GPI attachment to proteins 1
    Names
    CG3160-PA
    PGAP1-PA
    NP_572245.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5685253..5689473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132017.2 → NP_572245.1  Post-GPI attachment to proteins 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8Q8, Q9W495
      Related
      FBpp0070812
      Conserved Domains (1) summary
      pfam07819
      Location:79 → 324
      PGAP1; PGAP1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W495.3 Q9W495

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