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    Ift74 intraflagellar transport 74 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313365, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ift74provided by RGD
    Official Full Name
    intraflagellar transport 74provided by RGD
    Primary source
    RGD:1359704
    See related
    EnsemblRapid:ENSRNOG00000008075 AllianceGenome:RGD:1359704
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc2
    Summary
    Predicted to enable beta-tubulin binding activity and chromatin binding activity. Predicted to be involved in intraciliary transport involved in cilium assembly. Predicted to act upstream of or within several processes, including keratinocyte development; negative regulation of keratinocyte proliferation; and non-motile cilium assembly. Predicted to be located in centrosome and nucleus. Predicted to be part of intraciliary transport particle B. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Orthologous to human IFT74 (intraflagellar transport 74). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 325.8), Brain (RPKM 66.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ift74 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (114576106..114679581)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (109460372..109563839)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (113579065..113682485)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102920 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene phospholipase A2, activating protein Neighboring gene leucine rich repeat containing 19 Neighboring gene microRNA 872 Neighboring gene TEK receptor tyrosine kinase Neighboring gene equatorin Neighboring gene myb-like, SWIRM and MPN domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells. Fujino RS, et al. Mol Reprod Dev, 2006 Aug. PMID 16705683
    2. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Bhogaraju S, et al. Science, 2013 Aug 30. PMID 23990561, Free PMC Article
    3. Novel role for the intraflagellar transport protein CMG-1 in regulating the transcription of cyclin-D2, E-cadherin and integrin-alpha family genes in mouse spermatocyte-derived cells. Ichiro Ohbayashi K, et al. Genes Cells, 2010 Jun. PMID 20545763
    4. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. Bell SE, et al. J Cell Sci, 2001 Aug. PMID 11683410
    5. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Howard PW, et al. Exp Cell Res, 2013 Aug 15. PMID 23810713, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94371

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within keratinocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 74 homolog
    Names
    coiled-coil domain containing 2
    intraflagellar transport 74 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007001.1 → NP_001007002.1  intraflagellar transport protein 74 homolog

      See identical proteins and their annotated locations for NP_001007002.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083611
      UniProtKB/TrEMBL
      F7FIM8, Q5XIR2
      Related
      ENSRNOP00000011336.3, ENSRNOT00000011336.6
      Conserved Domains (2) summary
      COG1196
      Location:219 → 590
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd21341
      Location:7 → 63
      TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      114576106..114679581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593367.3 → XP_017448856.1  intraflagellar transport protein 74 homolog isoform X1

      UniProtKB/TrEMBL
      F7FIM8, Q5XIR2
      Conserved Domains (2) summary
      COG1196
      Location:219 → 590
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd21341
      Location:7 → 63
      TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

    2. XM_063287637.1 → XP_063143707.1  intraflagellar transport protein 74 homolog isoform X2

    3. XM_039109896.2 → XP_038965824.1  intraflagellar transport protein 74 homolog isoform X3

      Conserved Domains (1) summary
      COG1196
      Location:99 → 470
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version

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