sgg shaggy [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sggprovided by FlyBase
Official Full Name: shaggyprovided by FlyBase
Primary source: FLYBASE:FBgn0003371
Locus tag: Dmel_CG2621
See related: AllianceGenome:FB:FBgn0003371
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including learning; regionalization; and regulation of signal transduction. Located in several cellular components, including female germline ring canal; fusome; and microtubule cytoskeleton. Part of beta-catenin destruction complex. Is expressed in several structures, including brain; epithelium; germ layer; gut section; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to several human genes including GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3A8-3B1; 1-1 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2633952..2679553)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2527985..2573586)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila.
Title: A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila.
SCF-Slimb is critical for Glycogen synthase kinase-3beta-mediated suppression of TAF15-induced neurotoxicity in Drosophila.
Title: SCF-Slimb is critical for Glycogen synthase kinase-3β-mediated suppression of TAF15-induced neurotoxicity in Drosophila.
Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy.
Title: Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy.
Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism.
Title: Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.
Mitochondrial function leads to extensive glycogen accumulation late in oogenesis and is required for the developmental competence of the oocyte. Decreased insulin signaling initiates ETC remodeling and mitochondrial respiratory quiescence through glycogen synthase kinase 3 (GSK3).
Title: Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction.
Drosophila-based findings highlight an apical role for Hyd and Sgg in initiating Hedgehog signalling, which could also be evolutionarily conserved in mammals
Title: Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy.
Results show that downregulation of GSK3 promotes synapse formation in Drosophila neurons. However in rats hippocampal neurons, GSK3 inhibition yields to decrease of synapses in young neurons culture and the opposite in aged culture.
Title: GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.
upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD
Title: Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.
The Par-1/GSK-3/Slimb pathway plays important roles in limiting the amount of pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational repression.
Title: Oskar is targeted for degradation by the sequential action of Par-1, GSK-3, and the SCF⁻Slimb ubiquitin ligase.
GSK-3 is required for biderectional axonal transport.
Title: Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

fb33b12.x1 (e-PCR)
- UniSTS:190403

Dm0140 (e-PCR)
- UniSTS:30421

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in chitin-based larval cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of epithelial cell planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of epithelial cell planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic metaphase/anaphase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteolysis involved in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in pseudocleavage involved in syncytial blastoderm formation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein import into nucleus	TAS Traceable Author Statement more info	PubMed
involved_in regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to anesthetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic behavior	TAS Traceable Author Statement more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing and notum subfield formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin destruction complex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	HDA more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in female germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: shaggy

Names: CG2621-PA; CG2621-PB; CG2621-PC; CG2621-PD; CG2621-PE; CG2621-PF; CG2621-PG; CG2621-PH; CG2621-PI; CG2621-PJ; CG2621-PK; CG2621-PM; CG2621-PN; CG2621-PO; CG2621-PP; CG2621-PQ; CG2621-PR; CG2621-PS; CG2621-PT; GSK-3 kinase; GSK3betagr; Shaggy/Glycogen synthase kinase 3; Shaggy/Zeste-white-3/Glycogen synthase kinase 3beta; Zeste-white3; Zw3 kinase; glycogen synthase Kinase-3; glycogen synthase kinase 3; glycogen synthase kinase 3Beta; glycogen synthase kinase-3beta; saggy; sgg-PA; sgg-PB; sgg-PC; sgg-PD; sgg-PE; sgg-PF; sgg-PG; sgg-PH; sgg-PI; sgg-PJ; sgg-PK; sgg-PM; sgg-PN; sgg-PO; sgg-PP; sgg-PQ; sgg-PR; sgg-PS; sgg-PT; shaggy-zeste white 3; shaggy/zeste-white 3; zest-white 3; zeste white 3; zeste white-3; zeste white3; zeste-white 3; zestewhite-3

NP_001036259.2

EC 2.7.11.1

NP_001096870.1

EC 2.7.11.1

NP_001162649.1

EC 2.7.11.1

NP_001162650.1

EC 2.7.11.1

NP_001259192.1

EC 2.7.11.1

NP_001259193.1

EC 2.7.11.1

NP_001401051.1

EC 2.7.11.1

NP_001401052.1

EC 2.7.11.1

NP_476714.1

EC 2.7.11.1

NP_476715.1

EC 2.7.11.1

NP_476716.2

EC 2.7.11.1

NP_599105.1

EC 2.7.11.1

NP_726822.1

EC 2.7.11.1

NP_726823.1

EC 2.7.11.1

NP_996334.1

EC 2.7.11.1

NP_996335.1

EC 2.7.11.1

NP_996336.1

EC 2.7.11.1

NP_996337.1

EC 2.7.11.1

NP_996338.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2633952..2679553

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057366.5 → NP_476714.1 shaggy, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476714.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V3W1

Related

FBpp0070450

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_206613.3 → NP_996336.1 shaggy, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996336.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V3W1

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_166948.4 → NP_726823.1 shaggy, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726823.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76881, P18431, P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3

UniProtKB/TrEMBL

A4V3W2

Related

FBpp0070452

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_206614.3 → NP_996337.1 shaggy, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76881, P18431, P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3

UniProtKB/TrEMBL

A4V3W2

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_166947.3 → NP_726822.1 shaggy, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726822.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76881, P18431, P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3

UniProtKB/TrEMBL

A4V3W2

Related

FBpp0070451

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_057367.5 → NP_476715.1 shaggy, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476715.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76881, P18431, P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3

UniProtKB/TrEMBL

A4V3W2

Related

FBpp0070449

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_206615.2 → NP_996338.1 shaggy, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996338.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76881, P18431, P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3

UniProtKB/TrEMBL

A4V3W2

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_134278.3 → NP_599105.1 shaggy, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599105.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76881, P18431, P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3

UniProtKB/TrEMBL

A4V3W2

Related

FBpp0070453

Conserved Domains (2) summary

smart00220
Location:54 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:50 → 341

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001169178.1 → NP_001162649.1 shaggy, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162649.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVY5

Conserved Domains (1) summary

cd14137
Location:1 → 243

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001042794.4 → NP_001036259.2 shaggy, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036259.2

Status: REVIEWED

UniProtKB/TrEMBL

Q0KHW6

Conserved Domains (2) summary

smart00220
Location:76 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:72 → 363

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_206612.3 → NP_996335.1 shaggy, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996335.1

Status: REVIEWED

UniProtKB/TrEMBL

B6IDN4

Conserved Domains (2) summary

smart00220
Location:36 → 320

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:32 → 323

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001169179.1 → NP_001162650.1 shaggy, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162650.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PUX5

Conserved Domains (1) summary

cd14137
Location:1 → 243

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001414067.1 → NP_001401051.1 shaggy, isoform S [Drosophila melanogaster]

Status: REVIEWED
NM_206611.2 → NP_996334.1 shaggy, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996334.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVY5

Conserved Domains (1) summary

cd14137
Location:1 → 243

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001272264.1 → NP_001259193.1 shaggy, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259193.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGV7

Conserved Domains (2) summary

smart00220
Location:647 → 931

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:643 → 934

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001272263.1 → NP_001259192.1 shaggy, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259192.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGC4

Conserved Domains (2) summary

smart00220
Location:647 → 950

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:643 → 953

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_057368.5 → NP_476716.2 shaggy, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476716.2

Status: REVIEWED

UniProtKB/TrEMBL

H5V852

Related

FBpp0070454

Conserved Domains (2) summary

smart00220
Location:607 → 891

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:603 → 894

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001103400.2 → NP_001096870.1 shaggy, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096870.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JUV9

Conserved Domains (2) summary

smart00220
Location:288 → 535

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14137
Location:284 → 538

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
NM_001414068.1 → NP_001401052.1 shaggy, isoform T [Drosophila melanogaster]

Status: REVIEWED

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A4V3W1		A4V3W1
A4V3W2		A4V3W2
A8JUV9		A8JUV9
C0PUX5		C0PUX5
M9PGC4		M9PGC4
M9PGV7		M9PGV7
P18431.3		P18431
Q0KHW6		Q0KHW6
Q6A4R5		Q6A4R5
Q6A4R8		Q6A4R8
Q6A4S5		Q6A4S5
Q6A4T5		Q6A4T5
Q6A4T7		Q6A4T7
Q6A4W4		Q6A4W4
Q6A4W6		Q6A4W6
Q7KVY5		Q7KVY5