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    Pofut1 protein O-fucosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pofut1provided by RGD
    Official Full Name
    protein O-fucosyltransferase 1provided by RGD
    Primary source
    RGD:1303001
    See related
    EnsemblRapid:ENSRNOG00000010104 AllianceGenome:RGD:1303001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fut12; O-FucT-1
    Summary
    Predicted to enable peptide-O-fucosyltransferase activity. Predicted to be involved in protein O-linked fucosylation and regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including Notch signaling pathway; circulatory system development; and somitogenesis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 115.8), Kidney (RPKM 113.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pofut1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162168855..162195798)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141708618..141735558)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148722864..148749743)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene testis specific protein, Y-linked 26 Neighboring gene PLAG1 like zinc finger 2 Neighboring gene ribosomal protein L27A like 6 Neighboring gene kinesin family member 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycosylation regulates Notch signalling. Haines N, et al. Nat Rev Mol Cell Biol, 2003 Oct. PMID 14570055
    2. O-fucosylation of notch occurs in the endoplasmic reticulum. Luo Y, et al. J Biol Chem, 2005 Mar 25. PMID 15653671
    3. Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains. Wang Y, et al. Glycobiology, 1996 Dec. PMID 9023546
    4. Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. McMillan BJ, et al. Glycobiology, 2017 Aug 1. PMID 28334865, Free PMC Article
    5. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. Wang Y, et al. J Biol Chem, 2001 Oct 26. PMID 11524432

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide-O-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-O-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    GDP-fucose protein O-fucosyltransferase 1
    Names
    peptide-O-fucosyltransferase 1
    NP_001002278.1
    XP_017447268.1
    XP_038960997.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002278.3 → NP_001002278.1  GDP-fucose protein O-fucosyltransferase 1 precursor

      See identical proteins and their annotated locations for NP_001002278.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6EV70
      UniProtKB/TrEMBL
      A6KHU6
      Related
      ENSRNOP00000013730.2, ENSRNOT00000013730.5
      Conserved Domains (1) summary
      cd11302
      Location:37 → 386
      O-FucT-1; GDP-fucose protein O-fucosyltransferase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      162168855..162195798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591779.3 → XP_017447268.1  GDP-fucose protein O-fucosyltransferase 1 isoform X1

    2. XM_039105069.2 → XP_038960997.1  GDP-fucose protein O-fucosyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cd11302
      Location:1 → 271
      O-FucT-1; GDP-fucose protein O-fucosyltransferase 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6EV70.1 GenPept UniProtKB/Swiss-Prot:Q6EV70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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