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    DAAM Dishevelled Associated Activator of Morphogenesis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAAMprovided by FlyBase
    Official Full Name
    Dishevelled Associated Activator of Morphogenesisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025641
    Locus tag
    Dmel_CG14622
    See related
    AllianceGenome:FB:FBgn0025641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey148; CG14622; daam; Daam; daam1; Daam1; DAAM1; dDaam; dDAAM; Dmel\CG14622; EG:114D9.2
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Involved in several processes, including actin filament organization; axonogenesis; and positive regulation of cellular component organization. Located in several cellular components, including axonal growth cone; presynaptic active zone; and sarcomere. Is expressed in several structures, including brain; gut section; head epidermis primordium; mesoderm; and somatic muscle cell. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to several human genes including DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DAAM in Genome Data Viewer
    Location:
    1F2-1F3; 1-0.1 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1289713..1322362, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1183746..1216395, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Activating transcription factor 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46248 Neighboring gene uncharacterized protein Neighboring gene female sterile (1) Nasrat Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DAAM family members leading a novel path into formin research. Prokop A, et al. Commun Integr Biol, 2011 Sep. PMID 22046456, Free PMC Article
    2. Characterization of the biochemical properties and biological function of the formin homology domains of Drosophila DAAM. Barkó S, et al. J Biol Chem, 2010 Apr 23. PMID 20177055, Free PMC Article
    3. The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones. Szikora S, et al. J Cell Sci, 2017 Aug 1. PMID 28606990
    4. The activities of the C-terminal regions of the formin protein disheveled-associated activator of morphogenesis (DAAM) in actin dynamics. Vig AT, et al. J Biol Chem, 2017 Aug 18. PMID 28642367, Free PMC Article
    5. Molecular Dissection of DAAM Function during Axon Growth in Drosophila Embryonic Neurons. Földi I, et al. Cells, 2022 Apr 28. PMID 35563792, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.
      Title: FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.
    2. DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila.
      Title: DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila.
    3. Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
      Title: Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
    4. DAAM as an essential for both dextral and sinistral development.
      Title: The Drosophila actin nucleator DAAM is essential for left-right asymmetry.
    5. DAAM is an important cytoskeletal effector element of the Wg/Ank2 pathway involved in the determination of basic synaptic structures, and, additionally, that DAAM may couple the active zone scaffold to the presynaptic cytoskeleton.
      Title: Microtubule organization in presynaptic boutons relies on the formin DAAM.
    6. Together, these data suggest that, besides operating as an actin assembly factor, DAAM is involved in linking actin remodeling in filopodia to microtubule stabilization during axonal growth.
      Title: The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones.
    7. Data suggest that C-terminus, formin-homology domain contributes to DAAM-mediated filopodia formation and actin cytoskeletal dynamics in primary neurons.
      Title: The activities of the C-terminal regions of the formin protein disheveled-associated activator of morphogenesis (DAAM) in actin dynamics.
    8. Frl cooperates with DAAM during axon growth in the mushroom body
      Title: Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.
    9. This study have shown that the formin dDAAM plays an important role in the regulation of axonal growth and guidance of the Drosophila MB neurons.
      Title: The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila.
    10. our data suggest that dDAAM is required for the initial assembly of thin filaments, and subsequently it promotes filament elongation by assembling short actin polymers
      Title: DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c1311392-1311331 mobile_element_type = transposon:INE-1{}5416

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle thin filament assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sarcomere organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of tube architecture, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dishevelled associated activator of morphogenesis
    Names
    CG14622-PA
    CG14622-PB
    CG14622-PD
    CG14622-PE
    CG14622-PF
    CG14622-PG
    DAAM-PA
    DAAM-PB
    DAAM-PD
    DAAM-PE
    DAAM-PF
    DAAM-PG
    DIA-like
    formin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1289713..1322362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166875.3 → NP_726723.2  dishevelled associated activator of morphogenesis, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726723.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KW17, Q8IRY0, Q8MT16
      Conserved Domains (4) summary
      pfam02181
      Location:640 → 1018
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:241 → 427
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:39 → 238
      Drf_GBD; Diaphanous GTPase-binding Domain
      pfam16515
      Location:471 → 559
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    2. NM_001272197.1 → NP_001259126.1  dishevelled associated activator of morphogenesis, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KW17, Q8IRY0, Q8MT16
      Conserved Domains (4) summary
      pfam02181
      Location:640 → 1018
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:241 → 427
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:39 → 238
      Drf_GBD; Diaphanous GTPase-binding Domain
      pfam16515
      Location:471 → 559
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    3. NM_130544.4 → NP_569900.3  dishevelled associated activator of morphogenesis, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569900.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZA4, Q8MT16
      Related
      FBpp0070231
      Conserved Domains (4) summary
      pfam02181
      Location:601 → 979
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:202 → 388
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:1 → 199
      Drf_GBD; Diaphanous GTPase-binding Domain
      pfam16515
      Location:432 → 520
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    4. NM_001297842.1 → NP_001284771.1  dishevelled associated activator of morphogenesis, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KW17, Q8IRY0, Q8MT16
      Conserved Domains (4) summary
      pfam02181
      Location:640 → 1018
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:241 → 427
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:39 → 238
      Drf_GBD; Diaphanous GTPase-binding Domain
      pfam16515
      Location:471 → 559
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    5. NM_166876.3 → NP_726724.1  dishevelled associated activator of morphogenesis, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KW17, Q8IRY0, Q8MT16
      Related
      FBpp0070229
      Conserved Domains (4) summary
      pfam02181
      Location:640 → 1018
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:241 → 427
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:39 → 238
      Drf_GBD; Diaphanous GTPase-binding Domain
      pfam16515
      Location:471 → 559
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    6. NM_001201593.2 → NP_001188522.1  dishevelled associated activator of morphogenesis, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188522.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSM5
      Conserved Domains (4) summary
      pfam02050
      Location:779 → 875
      FliJ; Flagellar FliJ protein
      pfam02181
      Location:950 → 1328
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:551 → 737
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:349 → 548
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSM5 M9MSM5
    Q5BII2 Q5BII2
    Q7YZA4 Q7YZA4
    Q8IRY0 Q8IRY0
    Q8MT16 Q8MT16
    Q9W5A4 Q9W5A4

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