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    Tcp11 t-complex 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcp11provided by RGD
    Official Full Name
    t-complex 11provided by RGD
    Primary source
    RGD:1359387
    See related
    EnsemblRapid:ENSRNOG00000000499 AllianceGenome:RGD:1359387
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; protein kinase A signaling; and regulation of sperm capacitation. Predicted to be located in sperm midpiece. Predicted to be active in acrosomal vesicle and sperm flagellum. Orthologous to human TCP11 (t-complex 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1030.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcp11 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6128001..6140152, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6126267..6138408, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7645619..7657222, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene uncharacterized LOC102552617 Neighboring gene uncharacterized LOC108349039 Neighboring gene uncharacterized LOC120098860 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FPP modulates mammalian sperm function via TCP-11 and the adenylyl cyclase/cAMP pathway. Adeoya-Osiguwa SA, et al. Mol Reprod Dev, 1998 Dec. PMID 9820206
    2. Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. Liu Y, et al. Tohoku J Exp Med, 2011 Jun. PMID 21597245
    3. TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction. Fraser LR, et al. Mol Reprod Dev, 1997 Nov. PMID 9322250
    4. A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation. Stanger SJ, et al. FASEB J, 2016 Aug. PMID 27105888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95257

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein kinase A signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 11 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007695.1 → NP_001007696.1  T-complex protein 11 homolog

      See identical proteins and their annotated locations for NP_001007696.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083899
      UniProtKB/Swiss-Prot
      Q5XI00
      UniProtKB/TrEMBL
      A6JJP5
      Related
      ENSRNOP00000039755.4, ENSRNOT00000045044.6
      Conserved Domains (1) summary
      pfam05794
      Location:143 → 547
      Tcp11; T-complex protein 11

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6128001..6140152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601645.3 → XP_017457134.1  T-complex protein 11 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6GK20, A6JJP5
      Related
      ENSRNOP00000092987.1, ENSRNOT00000109959.2
      Conserved Domains (1) summary
      pfam05794
      Location:64 → 468
      Tcp11; T-complex protein 11

    2. XM_017601644.3 → XP_017457133.1  T-complex protein 11 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5XI00
      UniProtKB/TrEMBL
      A6JJP5
      Conserved Domains (1) summary
      pfam05794
      Location:143 → 547
      Tcp11; T-complex protein 11

    3. XM_006256200.5 → XP_006256262.1  T-complex protein 11 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6GK20, A6JJP5
      Conserved Domains (1) summary
      pfam05794
      Location:64 → 468
      Tcp11; T-complex protein 11

    4. XM_063279128.1 → XP_063135198.1  T-complex protein 11 homolog isoform X2

      UniProtKB/TrEMBL
      A6JJP5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI00.1 GenPept UniProtKB/Swiss-Prot:Q5XI00

    Gene LinkOut

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