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    Sh3pxd2a SH3 and PX domains 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sh3pxd2aprovided by RGD
    Official Full Name
    SH3 and PX domains 2Aprovided by RGD
    Primary source
    RGD:1311185
    See related
    EnsemblRapid:ENSRNOG00000089802 AllianceGenome:RGD:1311185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sh3md1
    Summary
    Predicted to enable several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in osteoclast fusion and superoxide anion generation. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in podosome. Predicted to be active in cytoplasm. Orthologous to human SH3PXD2A (SH3 and PX domains 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 125.1), Heart (RPKM 112.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3pxd2a in Genome Data Viewer
    Location:
    1q54
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256094991..256301120, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246153660..246359806, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267039654..267245868, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator 3 Neighboring gene neuralized E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC102552122 Neighboring gene transfer RNA proline (anticodon AGG) 27 Neighboring gene uncharacterized LOC134485242 Neighboring gene STN1 subunit of CST complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. Blouw B, et al. Eur J Cell Biol, 2008 Sep. PMID 18417249, Free PMC Article
    2. Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Diaz B, et al. Sci Signal, 2009 Sep 15. PMID 19755709, Free PMC Article
    3. Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion. Oikawa T, et al. J Cell Biol, 2012 May 14. PMID 22584907, Free PMC Article
    4. Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Gianni D, et al. Eur J Cell Biol, 2011 Feb-Mar. PMID 20609497, Free PMC Article
    5. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. Abram CL, et al. J Biol Chem, 2003 May 9. PMID 12615925

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables superoxide-generating NADPH oxidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoclast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 and PX domain-containing protein 2A
    Names
    SH3 multiple domains 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107606.3 → NP_001101076.2  SH3 and PX domain-containing protein 2A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6G2U9, D3ZMW5
      Related
      ENSRNOP00000102896.1, ENSRNOT00000149640.1

    2. NM_001415946.2 → NP_001402875.1  SH3 and PX domain-containing protein 2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AD93, D3ZMW5
      Related
      ENSRNOP00000109997.1, ENSRNOT00000139157.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      256094991..256301120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231514.5 → XP_006231576.1  SH3 and PX domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP29, D3ZMW5
      Related
      ENSRNOP00000102627.1, ENSRNOT00000123173.1
      Conserved Domains (6) summary
      cd06888
      Location:6 → 124
      PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
      cd12019
      Location:810 → 861
      SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12020
      Location:1039 → 1095
      SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12074
      Location:170 → 222
      SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12077
      Location:241 → 294
      SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12079
      Location:422 → 475
      SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains

    2. XM_039080588.2 → XP_038936516.1  SH3 and PX domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX92, A6JHQ5
      Conserved Domains (6) summary
      cd12019
      Location:787 → 838
      SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12020
      Location:1016 → 1072
      SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12074
      Location:119 → 171
      SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12077
      Location:218 → 271
      SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cd12079
      Location:399 → 452
      SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
      cl02563
      Location:1 → 73
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version

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