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    Cox15 cytochrome c oxidase assembly homolog COX15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309391, updated on 9-Dec-2024

    Summary

    Symbol
    Cox15provided by RGD
    Full Name
    cytochrome c oxidase assembly homolog COX15provided by RGD
    Primary source
    RGD:1312043
    See related
    EnsemblRapid:ENSRNOG00000017230 AllianceGenome:RGD:1312043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor and oxidoreductase activity, acting on the CH-CH group of donors. Predicted to be involved in cytochrome complex assembly and heme A biosynthetic process. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of cytochrome complex. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 206.0), Kidney (RPKM 151.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cox15 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252554811..252571471, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242605588..242622279, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263494850..263511510, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 28 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cutC copper transporter Neighboring gene cystatin B, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC124864

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxidoreductase activity, acting on the CH-CH group of donors ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cytochrome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of cytochrome complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    COX15 homolog
    Names
    COX15 cytochrome c oxidase assembly homolog
    COX15 homolog, cytochrome c oxidase assembly protein
    cytochrome c oxidase assembly homolog 15
    cytochrome c oxidase assembly protein COX15 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033699.4NP_001028871.2  COX15 homolog

      See identical proteins and their annotated locations for NP_001028871.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JHD6, D4A414, I6L9I0
      Related
      ENSRNOP00000023215.3, ENSRNOT00000023215.7
      Conserved Domains (1) summary
      pfam02628
      Location:74400
      COX15-CtaA; Cytochrome oxidase assembly protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      252554811..252571471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)