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    Ttc23 tetratricopeptide repeat domain 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc23provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 23provided by RGD
    Primary source
    RGD:1310409
    See related
    EnsemblRapid:ENSRNOG00000013877 AllianceGenome:RGD:1310409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310409
    Summary
    Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in cilium. Orthologous to human TTC23 (tetratricopeptide repeat domain 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 62.4), Lung (RPKM 48.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc23 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (130656040..130739670)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (121245996..121329500)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128604324..128687900)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691157 Neighboring gene leucine rich repeat containing 28 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC108349234 Neighboring gene uncharacterized LOC120099844 Neighboring gene synemin Neighboring gene small ribosomal subunit protein eS27-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116076

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 23
    Names
    TPR repeat protein 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025681.1 → NP_001020852.2  tetratricopeptide repeat protein 23

      Status: VALIDATED

      Source sequence(s)
      BC097953
      UniProtKB/Swiss-Prot
      Q4V7F0
      Conserved Domains (2) summary
      sd00006
      Location:111 → 140
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:65 → 141
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      130656040..130739670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262554.1 → XP_063118624.1  tetratricopeptide repeat protein 23 isoform X3

      UniProtKB/Swiss-Prot
      Q4V7F0
      UniProtKB/TrEMBL
      F1LMW2

    2. XM_063262550.1 → XP_063118620.1  tetratricopeptide repeat protein 23 isoform X2

      UniProtKB/Swiss-Prot
      Q4V7F0
      UniProtKB/TrEMBL
      M0R9N4

    3. XM_017589157.3 → XP_017444646.1  tetratricopeptide repeat protein 23 isoform X2

      UniProtKB/Swiss-Prot
      Q4V7F0
      UniProtKB/TrEMBL
      M0R9N4
      Related
      ENSRNOP00000066210.2, ENSRNOT00000073355.4
      Conserved Domains (2) summary
      sd00006
      Location:102 → 131
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:202 → 269
      TPR_12; Tetratricopeptide repeat

    4. XM_008759516.4 → XP_008757738.1  tetratricopeptide repeat protein 23 isoform X2

      UniProtKB/Swiss-Prot
      Q4V7F0
      UniProtKB/TrEMBL
      M0R9N4
      Conserved Domains (2) summary
      sd00006
      Location:102 → 131
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:202 → 269
      TPR_12; Tetratricopeptide repeat

    5. XM_039112733.2 → XP_038968661.1  tetratricopeptide repeat protein 23 isoform X3

      UniProtKB/Swiss-Prot
      Q4V7F0
      UniProtKB/TrEMBL
      F1LMW2
      Related
      ENSRNOP00000018639.8, ENSRNOT00000018639.8
      Conserved Domains (1) summary
      pfam13424
      Location:202 → 269
      TPR_12; Tetratricopeptide repeat

    6. XM_063262570.1 → XP_063118640.1  tetratricopeptide repeat protein 23 isoform X6

    7. XM_039112738.2 → XP_038968666.1  tetratricopeptide repeat protein 23 isoform X4

      UniProtKB/Swiss-Prot
      Q4V7F0
      Conserved Domains (2) summary
      sd00006
      Location:87 → 116
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:187 → 254
      TPR_12; Tetratricopeptide repeat

    8. XM_039112740.2 → XP_038968668.1  tetratricopeptide repeat protein 23 isoform X4

      UniProtKB/Swiss-Prot
      Q4V7F0
      Conserved Domains (2) summary
      sd00006
      Location:87 → 116
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:187 → 254
      TPR_12; Tetratricopeptide repeat

    9. XM_063262551.1 → XP_063118621.1  tetratricopeptide repeat protein 23 isoform X2

      UniProtKB/Swiss-Prot
      Q4V7F0
      UniProtKB/TrEMBL
      M0R9N4

    10. XM_039112748.2 → XP_038968676.1  tetratricopeptide repeat protein 23 isoform X4

      UniProtKB/Swiss-Prot
      Q4V7F0
      Conserved Domains (2) summary
      sd00006
      Location:87 → 116
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:187 → 254
      TPR_12; Tetratricopeptide repeat

    11. XM_008759515.4 → XP_008757737.1  tetratricopeptide repeat protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q4V7F0
      UniProtKB/TrEMBL
      A0A0G2K6R3
      Related
      ENSRNOP00000073911.2, ENSRNOT00000078707.3
      Conserved Domains (2) summary
      sd00006
      Location:111 → 140
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:65 → 141
      TPR_12; Tetratricopeptide repeat

    12. XM_039112761.2 → XP_038968689.1  tetratricopeptide repeat protein 23 isoform X5

      Conserved Domains (1) summary
      pfam13424
      Location:145 → 215
      TPR_12; Tetratricopeptide repeat

    RNA

    1. XR_010052154.1 RNA Sequence

    2. XR_010052152.1 RNA Sequence

    3. XR_005505567.2 RNA Sequence

    4. XR_005505570.2 RNA Sequence

    5. XR_005505569.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7F0.1 GenPept UniProtKB/Swiss-Prot:Q4V7F0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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