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    Zbtb2 zinc finger and BTB domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb2provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 2provided by RGD
    Primary source
    RGD:1306621
    See related
    AllianceGenome:RGD:1306621
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB2 (zinc finger and BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 84.6), Lung (RPKM 48.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb2 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43232839..43252115, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40827457..40846733, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40914175..40933586, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484990 Neighboring gene A-kinase anchoring protein 12 Neighboring gene zinc finger and BTB domain containing 2 like Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZBTB2, a novel master regulator of the p53 pathway. Jeon BN, et al. J Biol Chem, 2009 Jul 3. PMID 19380588, Free PMC Article
    2. ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65. Kim MY, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25609694, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107460.1 → NP_001100930.1  zinc finger and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_001100930.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474052
      UniProtKB/TrEMBL
      A6KIL1, D4ABS0
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18193
      Location:3 → 117
      BTB_POZ_ZBTB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2)
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      43232839..43252115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110625.2 → XP_038966553.1  zinc finger and BTB domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6KIL1, D4ABS0
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18193
      Location:3 → 117
      BTB_POZ_ZBTB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2)
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039110632.2 → XP_038966560.1  zinc finger and BTB domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6KIL1, D4ABS0
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18193
      Location:3 → 117
      BTB_POZ_ZBTB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2)
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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