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    Slc2a12 solute carrier family 2 member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308028, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc2a12provided by RGD
    Official Full Name
    solute carrier family 2 member 12provided by RGD
    Primary source
    RGD:1310175
    See related
    EnsemblRapid:ENSRNOG00000011161 AllianceGenome:RGD:1310175
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in D-glucose transmembrane transport and circulatory system development. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in membrane. Orthologous to human SLC2A12 (solute carrier family 2 member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 77.0), Uterus (RPKM 55.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc2a12 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (24623558..24683577, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (22803068..22862204, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (24003625..24056373, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098885 Neighboring gene TATA-box binding protein like 1 Neighboring gene uncharacterized LOC102555830 Neighboring gene uncharacterized LOC134482585

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Waller AP, et al. Biochim Biophys Acta, 2013 Jan. PMID 23041416
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circulatory system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 12
    Names
    solute carrier family 2 (facilitated glucose transporter), member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107451.1 → NP_001100921.1  solute carrier family 2, facilitated glucose transporter member 12

      See identical proteins and their annotated locations for NP_001100921.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474002
      UniProtKB/TrEMBL
      A0A8I6A9T2, A6JUP8, D3ZNG4
      Related
      ENSRNOP00000015566.5, ENSRNOT00000015566.7
      Conserved Domains (1) summary
      cd17435
      Location:46 → 564
      MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      24623558..24683577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110423.2 → XP_038966351.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9T2, A6JUP8, D3ZNG4
      Conserved Domains (1) summary
      cd17435
      Location:46 → 564
      MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters

    2. XM_039110427.2 → XP_038966355.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:46 → 367
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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