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    elavl1a ELAV like RNA binding protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 30736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elavl1aprovided by ZNC
    Official Full Name
    ELAV like RNA binding protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-245
    See related
    Ensembl:ENSDARG00000038695 AllianceGenome:ZFIN:ZDB-GENE-990415-245
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hua; elra; zHuA; elavl1; fa25f08; fb59a02; fc60g02; wu:fa25f08; wu:fb59a02; wu:fc60g02
    Summary
    Enables single-stranded RNA binding activity. Acts upstream of with a positive effect on RNA stabilization. Acts upstream of or within erythrocyte differentiation and positive regulation of angiogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in oocyte and skeletal muscle. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See elavl1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37123338..37134191, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37140881..37151734, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene zgc:101744 Neighboring gene solute carrier family 1 member 8b Neighboring gene tetraspanin 37 Neighboring gene peroxisomal biogenesis factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection. Ni S, et al. Commun Biol, 2021 Feb 26. PMID 33637956, Free PMC Article
    2. Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis. Zhou X, et al. Biochim Biophys Acta Mol Cell Res, 2019 Feb. PMID 30395882
    3. ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm. Zhou C, et al. Immunobiology, 2023 Jul. PMID 37343439
    4. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Prendergast A, et al. Development, 2012 Mar. PMID 22296847, Free PMC Article
    5. The expression of CPEB proteins is sequentially regulated during zebrafish oogenesis and embryogenesis. O'Connell ML, et al. Mol Reprod Dev, 2014 Apr. PMID 24474627

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm.
      Title: ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm.
    2. ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.
      Title: ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.
    3. this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 expression.
      Title: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect RNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ELAV-like protein 1a
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
    ELAV like RNA binding protein 1
    elav-related A
    embryonic lethal, abnormal vision-related A
    etID309757.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131452.1 → NP_571527.1  ELAV-like protein 1a

      See identical proteins and their annotated locations for NP_571527.1

      Status: PROVISIONAL

      Source sequence(s)
      AF184244
      UniProtKB/TrEMBL
      Q9PTK5
      Related
      ENSDARP00000040426.5, ENSDART00000040427.6
      Conserved Domains (4) summary
      cd12650
      Location:17 → 94
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12773
      Location:104 → 187
      RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)
      TIGR01661
      Location:15 → 324
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:241 → 324
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      37123338..37134191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222966.1 → XP_068079067.1  ELAV-like protein 1a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AQB0

    2. XM_009298634.2 → XP_009296909.1  ELAV-like protein 1a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AQB0
      Conserved Domains (1) summary
      cl17169
      Location:127 → 210
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_005171267.5 → XP_005171324.1  ELAV-like protein 1a isoform X1

      See identical proteins and their annotated locations for XP_005171324.1

      UniProtKB/TrEMBL
      A0A8M2BIL8, F1QM02
      Related
      ENSDARP00000120506.1, ENSDART00000146123.3
      Conserved Domains (4) summary
      cd12650
      Location:33 → 110
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12653
      Location:257 → 340
      RRM3_HuR; RNA recognition motif 3 in vertebrate Hu-antigen R (HuR)
      cd12773
      Location:120 → 203
      RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)
      TIGR01661
      Location:31 → 340
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. XM_017357655.2 → XP_017213144.1  ELAV-like protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIL8, F1QM02
      Conserved Domains (4) summary
      cd12650
      Location:33 → 110
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12653
      Location:257 → 340
      RRM3_HuR; RNA recognition motif 3 in vertebrate Hu-antigen R (HuR)
      cd12773
      Location:120 → 203
      RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)
      TIGR01661
      Location:31 → 340
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein Strain
    Heading Accession and Version

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