bmp2a bone morphogenetic protein 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmp2aprovided by ZNC
Official Full Name: bone morphogenetic protein 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-388
See related: Ensembl:ENSDARG00000013409 AllianceGenome:ZFIN:ZDB-GENE-980526-388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bmp2; wu:fc59d09
Summary: Predicted to enable cytokine activity. Acts upstream of or within exocrine pancreas development and positive regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; fin; fin bud; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); hemochromatosis type 1; otosclerosis; short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (4227274..4231388, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (4068873..4072987, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway.
Title: lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway.
Mypt1 regulates Bmp signaling to promote embryonic exocrine pancreas growth in zebrafish.
Title: Mypt1 regulates Bmp signaling to promote embryonic exocrine pancreas growth in zebrafish.
Study found that BMP-2 is negatively regulated by miR-140 during early embryogenesis and bone development in zebra fi sh.
Title: MicroRNA-140-5p impairs zebrafish embryonic bone development via targeting BMP-2.
Structures of Bmp2a, Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
Title: Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives.
bmp2a is a crucial player in the specification of the ventral pancreatic bud in zebrafish embryos.
Title: Essential roles of zebrafish bmp2a, fgf10, and fgf24 in the specification of the ventral pancreas.
results indicate that both the induction of a photoreceptor fate and the interaction with Notch relies on a canonical BMP/Smad5 pathway
Title: BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch.
Mypt1 mediates coordination between mesoderm and endoderm cell movements in order to carefully position the liver primordium such that it receives a Bmp2 signal that is essential for liver formation
Title: Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis.

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General gene information

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Markers

fc59d09 (e-PCR)
- UniSTS:189443

BMP2a (e-PCR)
- UniSTS:205403

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exocrine pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131359.1 → NP_571434.1 bone morphogenetic protein 2 precursor

See identical proteins and their annotated locations for NP_571434.1

Status: PROVISIONAL

Source sequence(s)

U82233

UniProtKB/TrEMBL

O13109

Related

ENSDARP00000013686.5, ENSDART00000019364.7

Conserved Domains (2) summary

smart00204
Location:286 → 386

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:28 → 256

TGFb_propeptide; TGF-beta propeptide