Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pinx1provided by RGD
Official Full Name: PIN2/TERF1 interacting, telomerase inhibitor 1provided by RGD
Primary source: RGD:1566025
See related: EnsemblRapid:ENSRNOG00000012012 AllianceGenome:RGD:1566025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566025
Summary: Predicted to enable telomerase RNA binding activity and telomerase inhibitor activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Predicted to act upstream of or within telomere maintenance via telomerase. Predicted to be located in several cellular components, including chromosome; nucleoplasm; and spindle. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 39.5), Spleen (RPKM 34.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (42273805..42333047)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (38097896..38157143)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (47211682..47270343)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity.
Title: Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity.

Submit: New GeneRIF Correction

General gene information

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Markers

BQ195852 (e-PCR)
- UniSTS:260626

RH128783 (e-PCR)
- UniSTS:212091

RH132666 (e-PCR)
- UniSTS:215949

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	IEA Inferred from Electronic Annotation more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info
enables telomerase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables telomerase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitotic metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleolus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleolus	IEA Inferred from Electronic Annotation more info
involved_in protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear chromosome	IEA Inferred from Electronic Annotation more info
located_in nuclear chromosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PIN2/TERF1-interacting telomerase inhibitor 1

Names: PIN2-interacting protein 1; Pin2-interacting protein X1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083337.2 → NP_001076806.1 PIN2/TERF1-interacting telomerase inhibitor 1

See identical proteins and their annotated locations for NP_001076806.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

A4L691

UniProtKB/TrEMBL

B0BMT3

Related

ENSRNOP00000016027.4, ENSRNOT00000016027.7

Conserved Domains (1) summary

smart00443
Location:24 → 69

G_patch; glycine rich nucleic binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

42273805..42333047

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274286.1 → XP_063130356.1 PIN2/TERF1-interacting telomerase inhibitor 1 isoform X4
XM_006252181.5 → XP_006252243.1 PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A1H3

Related

ENSRNOP00000085367.1, ENSRNOT00000102140.2

Conserved Domains (1) summary

smart00443
Location:59 → 104

G_patch; glycine rich nucleic binding domain
XM_039093331.2 → XP_038949259.1 PIN2/TERF1-interacting telomerase inhibitor 1 isoform X3

Conserved Domains (1) summary

smart00443
Location:59 → 104

G_patch; glycine rich nucleic binding domain
XM_039093329.2 → XP_038949257.1 PIN2/TERF1-interacting telomerase inhibitor 1 isoform X2

Conserved Domains (1) summary

smart00443
Location:59 → 104

G_patch; glycine rich nucleic binding domain