dlx5a distal-less homeobox 5a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dlx5aprovided by ZNC
Official Full Name: distal-less homeobox 5aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-49
See related: Ensembl:ENSDARG00000042296 AllianceGenome:ZFIN:ZDB-GENE-990415-49
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dlx4; zgc:101787
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; fin development; and olfactory nerve formation. Predicted to be located in nucleus. Is expressed in several structures, including dental epithelium; fin; forebrain; pectoral fin bud; and pharyngeal arch. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (41470216..41472228, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (41885161..41887173, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology.
Title: Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology.
Data show that dlx1a/2a and dlx5a/6a expressing progenitors give rise, for the most part, to small populations of cells which constitute only a small proportion of GABAergic cells in the adult brain tissue.
Title: Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain.
The data indicate distinct requirements for dlx5a/6a during median and pectoral fin development
Title: The dlx5a/dlx6a genes play essential roles in the early development of zebrafish median fin and pectoral structures.
Data suggest that zebrafish dlx5a/dlx6a intergenic cis-regulatory elements may be involved in a conserved genetic pathway necessary for proper dlx expression during zebrafish GABAergic neuron development.
Title: Activity of dlx5a/dlx6a regulatory elements during zebrafish GABAergic neuron development.
the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches
Title: hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chordate embryonic development	IEA Inferred from Electronic Annotation more info
involved_in embryonic morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within medial fin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory nerve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory placode morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pectoral fin development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Dlx5a

Names: distal-less homeobox gene 4; distal-less homeobox gene 5a; distal-less homeobox protein 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131306.2 → NP_571381.2 homeobox protein Dlx5a

Status: VALIDATED

Source sequence(s)

CU929240, EH449338, EH606041

UniProtKB/Swiss-Prot

P50576

UniProtKB/TrEMBL

A0A8M1P7I3, Q5XJL9

Related

ENSDARP00000100492.2, ENSDART00000113388.4

Conserved Domains (2) summary

pfam00046
Location:140 → 193

Homeobox; Homeobox domain

pfam12413
Location:31 → 118

DLL_N; Homeobox protein distal-less-like N terminal