Lamb3 laminin subunit beta 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamb3provided by RGD
Official Full Name: laminin subunit beta 3provided by RGD
Primary source: RGD:1562668
See related: EnsemblRapid:ENSRNOG00000006025 AllianceGenome:RGD:1562668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including basement membrane assembly; endodermal cell differentiation; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in basement membrane. Predicted to be part of laminin-5 complex. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1A; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to human LAMB3 (laminin subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 195.6), Thymus (RPKM 45.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (107362514..107404081)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (104833810..104875405)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (112031614..112073187)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
In bladder carcinoma laminin-332 can suppress the number of invadopodia that form by interacting with a3b1 integrin and altering the cellular balance of FAK and Src kinase activity.
Title: Laminin-332-beta1 integrin interactions negatively regulate invadopodia.
a complex of laminin alpha 3, beta3 and gamma3 chains serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes
Title: Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.

Submit: New GeneRIF Correction

General gene information

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Markers

BE101834 (e-PCR)
- UniSTS:243752

Lamb3 (e-PCR), detects polymorphism
- UniSTS:143753

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of laminin-5 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit beta-3

Names: laminin chain; laminin, beta 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100841.1 → NP_001094311.1 laminin subunit beta-3 precursor

See identical proteins and their annotated locations for NP_001094311.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6JH29, F1LPI5

Related

ENSRNOP00000008440.4, ENSRNOT00000008440.8

Conserved Domains (5) summary

smart00180
Location:535 → 572

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:431 → 480

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:380 → 429

Laminin_EGF; Laminin EGF domain

cl02488
Location:909 → 1092

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02806
Location:21 → 249

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

107362514..107404081

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769856.4 → XP_008768078.1 laminin subunit beta-3 isoform X1

See identical proteins and their annotated locations for XP_008768078.1

UniProtKB/TrEMBL

A6JH29, F1LPI5

Related

ENSRNOP00000107541.1, ENSRNOT00000121167.1

Conserved Domains (5) summary

smart00180
Location:535 → 572

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:431 → 480

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:380 → 429

Laminin_EGF; Laminin EGF domain

cl02488
Location:909 → 1092

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02806
Location:21 → 249

Laminin_N; Laminin N-terminal (Domain VI)