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    Angel2 angel homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Angel2provided by RGD
    Official Full Name
    angel homolog 2provided by RGD
    Primary source
    RGD:1305056
    See related
    EnsemblRapid:ENSRNOG00000003795 AllianceGenome:RGD:1305056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305056
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Predicted to be located in Cajal body and mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ANGEL2 (angel homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 86.5), Thymus (RPKM 84.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Angel2 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105041727..105060640)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102509111..102529501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109505021..109520976)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase C1 Neighboring gene uncharacterized LOC134481611 Neighboring gene H3.3 histone B like 1 Neighboring gene vasohibin 2 Neighboring gene FLVCR choline and heme transporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Wagner E, et al. Mol Cell Biol, 2007 Mar. PMID 17178830, Free PMC Article
    2. RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. Yi X, et al. J Biol Chem, 2012 Jun 15. PMID 22547059, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein angel homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135119.3 → NP_001128591.2  protein angel homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001128591.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGX6
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_001401388.1 → NP_001388317.1  protein angel homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LT13
      Related
      ENSRNOP00000005084.6, ENSRNOT00000005084.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105041727..105060640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090824.2 → XP_038946752.1  protein angel homolog 2 isoform X3

      UniProtKB/TrEMBL
      A6JGX7
      Conserved Domains (1) summary
      cl00490
      Location:169 → 369
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. XM_039090820.2 → XP_038946748.1  protein angel homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6JGX6
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. XM_039090821.2 → XP_038946749.1  protein angel homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6JGX6
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. XM_039090822.2 → XP_038946750.1  protein angel homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6JGX6
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    5. XM_039090823.2 → XP_038946751.1  protein angel homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6JGX6
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    6. XM_006250462.5 → XP_006250524.1  protein angel homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZF9
      Related
      ENSRNOP00000083532.1, ENSRNOT00000109060.2
      Conserved Domains (1) summary
      cl00490
      Location:43 → 416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    7. XM_039090825.2 → XP_038946753.1  protein angel homolog 2 isoform X4

      Conserved Domains (1) summary
      cl00490
      Location:8 → 298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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