Clic6 chloride intracellular channel 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clic6provided by RGD
Official Full Name: chloride intracellular channel 6provided by RGD
Primary source: RGD:727938
See related: EnsemblRapid:ENSRNOG00000026870 AllianceGenome:RGD:727938
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Clic6b
Summary: Enables dopamine receptor binding activity and identical protein binding activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human CLIC6 (chloride intracellular channel 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 22.8), Lung (RPKM 17.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (45223715..45266261)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (31737813..31780360)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (32655653..32698004)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G45351 (e-PCR)
- UniSTS:106153

5730466J16Rik (e-PCR), detects polymorphism
- UniSTS:259027

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D2 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D2 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables D3 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D3 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables D4 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D4 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chloride intracellular channel protein 6

Names: glutaredoxin-like oxidoreductase CLIC6; intracellular chloride channel 6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176078.3 → NP_788267.2 chloride intracellular channel protein 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q811Q2

UniProtKB/TrEMBL

A0A0G2JTB6, A6JLK3, F1M9X4

Related

ENSRNOP00000033206.5, ENSRNOT00000034383.6

Conserved Domains (2) summary

TIGR00862
Location:380 → 613

O-ClC; intracellular chloride channel protein

TIGR00927
Location:51 → 318

2A1904; K+-dependent Na+/Ca+ exchanger