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    Abi3 ABI family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abi3provided by RGD
    Official Full Name
    ABI family, member 3provided by RGD
    Primary source
    RGD:1311794
    See related
    EnsemblRapid:ENSRNOG00000005575 AllianceGenome:RGD:1311794
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity; identical protein binding activity; and signaling adaptor activity. Involved in modification of postsynaptic actin cytoskeleton. Is active in glutamatergic synapse and postsynapse. Orthologous to human ABI3 (ABI family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 209.2), Lung (RPKM 82.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abi3 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81266571..81277561, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (80769819..80780816, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83644086..83655182, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547047 Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1 Neighboring gene G protein subunit gamma transducin 2 Neighboring gene uncharacterized LOC134480858 Neighboring gene transfer RNA glutamine (anticodon UUG) 1 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NESH regulates dendritic spine morphology and synapse formation. Bae J, et al. PLoS One, 2012. PMID 22485184, Free PMC Article
    2. Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. Ichigotani Y, et al. Cancer Res, 2002 Apr 15. PMID 11956071
    3. NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. Hirao N, et al. FEBS Lett, 2006 Nov 27. PMID 17101133
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ABI gene family member 3
    Names
    ABI gene family, member 3
    NESH protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013118.1 → NP_001013136.1  ABI gene family member 3

      See identical proteins and their annotated locations for NP_001013136.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079102
      UniProtKB/TrEMBL
      A0A8I5ZSD9, F7FKP3, Q6AYC6
      Related
      ENSRNOP00000007897.2, ENSRNOT00000007897.5
      Conserved Domains (2) summary
      cd11826
      Location:313 → 364
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96 → 167
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81266571..81277561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086071.2 → XP_038941999.1  ABI gene family member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSD9
      Conserved Domains (2) summary
      cd11826
      Location:312 → 363
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96 → 159
      Abi_HHR; Abl-interactor HHR

    2. XM_063269113.1 → XP_063125183.1  ABI gene family member 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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