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    ndrg3a ndrg family member 3a [ Danio rerio (zebrafish) ]

    Gene ID: 30286, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndrg3aprovided by ZNC
    Official Full Name
    ndrg family member 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-124
    See related
    Ensembl:ENSDARG00000013087 AllianceGenome:ZFIN:ZDB-GENE-980526-124
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ndr3; ndrg3; fc04h03; zgc:63551; wu:fc04h03
    Summary
    Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including corpuscles of Stannius; pectoral fin bud; pharyngeal pouch; pronephric duct; and thymus. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ndrg3a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (25064536..25139061)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24826884..24901445)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 46a Neighboring gene PHD finger protein 20, a Neighboring gene Src like adaptor 2a Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein a Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes. Zinani OQH, et al. iScience, 2022 Jul 15. PMID 35789861, Free PMC Article
    2. Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. Le N, et al. FASEB J, 2021 Nov. PMID 34665878, Free PMC Article
    3. Effects of NDRG1 family proteins on photoreceptor outer segment morphology in zebrafish. Takita S, et al. Sci Rep, 2016 Nov 4. PMID 27811999, Free PMC Article
    4. Periodic inhibition of Erk activity drives sequential somite segmentation. Simsek MF, et al. Nature, 2023 Jan. PMID 36517597, Free PMC Article
    5. N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. Park JS, et al. Elife, 2022 Oct 10. PMID 36214665, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    protein NDRG3a
    Names
    N-myc downstream regulated 3
    N-myc downstream regulated family member 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199517.1 → NP_955811.1  protein NDRG3a

      See identical proteins and their annotated locations for NP_955811.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055138
      UniProtKB/TrEMBL
      A0A8M1PDZ6, Q7SY38
      Related
      ENSDARP00000005974.9, ENSDART00000016181.11
      Conserved Domains (2) summary
      COG0596
      Location:41 → 311
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:31 → 316
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      25064536..25139061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479547.2 → XP_021335222.1  protein NDRG3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PUP4
      Conserved Domains (1) summary
      pfam03096
      Location:31 → 316
      Ndr; Ndr family

    2. XM_009306019.4 → XP_009304294.1  protein NDRG3a isoform X1

      See identical proteins and their annotated locations for XP_009304294.1

      UniProtKB/TrEMBL
      A0A8M9PUP4
      Conserved Domains (1) summary
      pfam03096
      Location:31 → 316
      Ndr; Ndr family

    3. XM_005169249.4 → XP_005169306.1  protein NDRG3a isoform X1

      See identical proteins and their annotated locations for XP_005169306.1

      UniProtKB/TrEMBL
      A0A8M9PUP4
      Related
      ENSDARP00000151480.1, ENSDART00000183700.1
      Conserved Domains (1) summary
      pfam03096
      Location:31 → 316
      Ndr; Ndr family

    4. XM_068224102.1 → XP_068080203.1  protein NDRG3a isoform X3

      UniProtKB/TrEMBL
      A0A8M1PDZ6, Q7SY38

    5. XM_005169250.5 → XP_005169307.1  protein NDRG3a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BGH5, E7FEZ7
      Related
      ENSDARP00000105614.2, ENSDART00000128705.3
      Conserved Domains (2) summary
      COG0596
      Location:28 → 298
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:18 → 303
      Ndr; Ndr family
    Nucleotide Protein Strain
    Heading Accession and Version

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