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    Stk11ip serine/threonine kinase 11 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stk11ipprovided by RGD
    Official Full Name
    serine/threonine kinase 11 interacting proteinprovided by RGD
    Primary source
    RGD:1305046
    See related
    EnsemblRapid:ENSRNOG00000020107 AllianceGenome:RGD:1305046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Orthologous to human STK11IP (serine/threonine kinase 11 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 59.4), Kidney (RPKM 36.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stk11ip in Genome Data Viewer
    Location:
    9q33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84459733..84476521)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (77012297..77027989)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82718343..82733894)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198 Neighboring gene obscurin like cytoskeletal adaptor 1 Neighboring gene inhibin subunit alpha Neighboring gene solute carrier family 4 member 3 Neighboring gene uncharacterized LOC120094715

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Smith DP, et al. Hum Mol Genet, 2001 Dec 1. PMID 11741830
    2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188315

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 11-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106922.3 → NP_001100392.2  serine/threonine-protein kinase 11-interacting protein isoform 7

      See identical proteins and their annotated locations for NP_001100392.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2, B4F7D6
      Related
      ENSRNOP00000074996.3, ENSRNOT00000080524.3
      Conserved Domains (4) summary
      sd00033
      Location:163 → 187
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:234 → 274
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:236 → 291
      LRR_8; Leucine rich repeat
      pfam15904
      Location:4 → 94
      LIP1; LKB1 serine/threonine kinase interacting protein 1

    2. NM_001432885.1 → NP_001419814.1  serine/threonine-protein kinase 11-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K9H2

    3. NM_001432901.1 → NP_001419830.1  serine/threonine-protein kinase 11-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2, F7F669

    4. NM_001432902.1 → NP_001419831.1  serine/threonine-protein kinase 11-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2, F7F669

    5. NM_001432903.1 → NP_001419832.1  serine/threonine-protein kinase 11-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K9H2

    6. NM_001432904.1 → NP_001419833.1  serine/threonine-protein kinase 11-interacting protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K9H2

    7. NM_001432905.1 → NP_001419834.1  serine/threonine-protein kinase 11-interacting protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2

    8. NM_001432906.1 → NP_001419835.1  serine/threonine-protein kinase 11-interacting protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2

    9. NM_001432907.1 → NP_001419836.1  serine/threonine-protein kinase 11-interacting protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2, B4F7D6

    10. NM_001432908.1 → NP_001419837.1  serine/threonine-protein kinase 11-interacting protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2

    11. NM_001432909.1 → NP_001419838.1  serine/threonine-protein kinase 11-interacting protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2

    12. NM_001432910.1 → NP_001419839.1  serine/threonine-protein kinase 11-interacting protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2

    13. NM_001432911.1 → NP_001419840.1  serine/threonine-protein kinase 11-interacting protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AVQ2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84459733..84476521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266993.1 → XP_063123063.1  serine/threonine-protein kinase 11-interacting protein isoform X16

      UniProtKB/TrEMBL
      A0A8I6AVQ2

    2. XM_063266980.1 → XP_063123050.1  serine/threonine-protein kinase 11-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9H2

    3. XM_063266983.1 → XP_063123053.1  serine/threonine-protein kinase 11-interacting protein isoform X4

      Related
      ENSRNOP00000092473.2, ENSRNOT00000115992.2

    4. XM_063266982.1 → XP_063123052.1  serine/threonine-protein kinase 11-interacting protein isoform X3

      UniProtKB/TrEMBL
      A0A0G2K9H2

    5. XM_063266984.1 → XP_063123054.1  serine/threonine-protein kinase 11-interacting protein isoform X5

      UniProtKB/TrEMBL
      A0A0G2K9H2

    6. XM_063266981.1 → XP_063123051.1  serine/threonine-protein kinase 11-interacting protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2K9H2

    7. XM_063266985.1 → XP_063123055.1  serine/threonine-protein kinase 11-interacting protein isoform X6

      UniProtKB/TrEMBL
      A0A0G2K9H2

    8. XM_039083376.2 → XP_038939304.1  serine/threonine-protein kinase 11-interacting protein isoform X7

      UniProtKB/TrEMBL
      A0A8I6AVQ2
      Conserved Domains (3) summary
      COG4886
      Location:101 → 323
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:163 → 187
      LRR_RI; leucine-rich repeat [structural motif]
      pfam15904
      Location:8 → 92
      LIP1; LKB1 serine/threonine kinase interacting protein 1

    9. XM_063266986.1 → XP_063123056.1  serine/threonine-protein kinase 11-interacting protein isoform X8

    10. XM_063266987.1 → XP_063123057.1  serine/threonine-protein kinase 11-interacting protein isoform X9

      Related
      ENSRNOP00000027256.7, ENSRNOT00000027256.8

    11. XM_063266988.1 → XP_063123058.1  serine/threonine-protein kinase 11-interacting protein isoform X10

    12. XM_063266989.1 → XP_063123059.1  serine/threonine-protein kinase 11-interacting protein isoform X11

    13. XM_063266991.1 → XP_063123061.1  serine/threonine-protein kinase 11-interacting protein isoform X14

    14. XM_063266990.1 → XP_063123060.1  serine/threonine-protein kinase 11-interacting protein isoform X12

    15. XM_006245188.5 → XP_006245250.1  serine/threonine-protein kinase 11-interacting protein isoform X13

      Conserved Domains (4) summary
      sd00033
      Location:163 → 187
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:234 → 274
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:236 → 291
      LRR_8; Leucine rich repeat
      pfam15904
      Location:4 → 94
      LIP1; LKB1 serine/threonine kinase interacting protein 1

    16. XM_063266992.1 → XP_063123062.1  serine/threonine-protein kinase 11-interacting protein isoform X15

    17. XM_063266994.1 → XP_063123064.1  serine/threonine-protein kinase 11-interacting protein isoform X17

    Nucleotide Protein Strain
    Heading Accession and Version

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