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    Slc25a23 solute carrier family 25 member 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301113, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc25a23provided by RGD
    Official Full Name
    solute carrier family 25 member 23provided by RGD
    Primary source
    RGD:1588586
    See related
    EnsemblRapid:ENSRNOG00000047781 AllianceGenome:RGD:1588586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ADP:phosphate antiporter activity and ATP:phosphate antiporter activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and purine ribonucleotide transport. Predicted to act upstream of or within several processes, including adenine nucleotide transport; cellular response to calcium ion; and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion. Orthologous to human SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 252.3), Liver (RPKM 238.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Slc25a23 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1969633..1985365, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1882636..1898369, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9987988..10003599)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase isoenzyme 5 Neighboring gene KH-type splicing regulatory protein Neighboring gene solute carrier family 25, member 41 Neighboring gene crumbs cell polarity complex component 3 Neighboring gene DENN domain containing 1C

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial adenyl nucleotide antiporter SLC25A23
    Names
    calcium-binding mitochondrial carrier protein SCaMC-3
    phosphate carrier), member 23
    solute carrier family 25 (mitochondrial carrier
    solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106873.3NP_001100343.1  mitochondrial adenyl nucleotide antiporter SLC25A23

      See identical proteins and their annotated locations for NP_001100343.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JVD2, A6KQS8
      Related
      ENSRNOP00000069437.2, ENSRNOT00000086575.3
      Conserved Domains (2) summary
      COG5126
      Location:7142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:189462
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1969633..1985365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083133.2XP_038939061.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X2

      Conserved Domains (3) summary
      COG5126
      Location:7142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:189426
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:184267
      Mito_carr; Mitochondrial carrier protein
    2. XM_017596319.3XP_017451808.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X1

      UniProtKB/TrEMBL
      M0R4V4
      Related
      ENSRNOP00000064402.2, ENSRNOT00000073000.4