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    Atrip ATR interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301014, updated on 9-Dec-2024

    Summary

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    Symbol
    Atripprovided by RGD
    Full Name
    ATR interacting proteinprovided by RGD
    Primary source
    RGD:1626390
    See related
    EnsemblRapid:ENSRNOG00000020670 AllianceGenome:RGD:1626390
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of ATR-ATRIP complex. Orthologous to human ATRIP (ATR interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 71.5), Spleen (RPKM 66.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atrip in Genome Data Viewer
    Location:
    8q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118586909..118600975, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109708440..109722511, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117797954..117811989, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene shisa family member 5 Neighboring gene three prime repair exonuclease 1 Neighboring gene U2 spliceosomal RNA Neighboring gene coiled-coil domain containing 51 Neighboring gene translation machinery associated 7 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATR and ATRIP: partners in checkpoint signaling. Cortez D, et al. Science, 2001 Nov 23. PMID 11721054
    2. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. Pabla N, et al. J Biol Chem, 2008 Mar 7. PMID 18162465
    3. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Maréchal A, et al. Mol Cell, 2014 Jan 23. PMID 24332808, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATR-ATRIP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATR-interacting protein
    Names
    ATR-interacting protein-like
    NP_001100329.1
    XP_006243829.1
    XP_038937169.1
    XP_038937170.1
    XP_038937171.1
    XP_038937172.1
    XP_063121327.1
    XP_063121328.1
    XP_063121329.1
    XP_063121330.1
    XP_063121331.1
    XP_063121332.1
    XP_063121333.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106859.1 → NP_001100329.1  ATR-interacting protein

      See identical proteins and their annotated locations for NP_001100329.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A6I3B3, D4A4M3
      Related
      ENSRNOP00000066012.4, ENSRNOT00000073395.4
      Conserved Domains (1) summary
      cl09111
      Location:115 → 207
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118586909..118600975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265260.1 → XP_063121330.1  ATR-interacting protein isoform X4

      UniProtKB/TrEMBL
      D4A4M3

    2. XM_063265258.1 → XP_063121328.1  ATR-interacting protein isoform X2

      UniProtKB/TrEMBL
      D4A4M3

    3. XM_063265259.1 → XP_063121329.1  ATR-interacting protein isoform X3

      UniProtKB/TrEMBL
      D4A4M3, M0R950
      Related
      ENSRNOP00000103050.1, ENSRNOT00000152970.1

    4. XM_063265257.1 → XP_063121327.1  ATR-interacting protein isoform X1

      UniProtKB/TrEMBL
      D4A4M3

    5. XM_063265261.1 → XP_063121331.1  ATR-interacting protein isoform X5

      UniProtKB/TrEMBL
      D4A4M3

    6. XM_063265263.1 → XP_063121333.1  ATR-interacting protein isoform X6

    7. XM_063265262.1 → XP_063121332.1  ATR-interacting protein isoform X6

    8. XM_039081242.2 → XP_038937170.1  ATR-interacting protein isoform X6

      Conserved Domains (2) summary
      COG0419
      Location:27 → 207
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl09111
      Location:118 → 207
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    9. XM_006243767.5 → XP_006243829.1  ATR-interacting protein isoform X5

      UniProtKB/TrEMBL
      D4A4M3
      Conserved Domains (1) summary
      cl09111
      Location:117 → 207
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    10. XM_039081241.2 → XP_038937169.1  ATR-interacting protein isoform X6

      Conserved Domains (2) summary
      COG0419
      Location:27 → 207
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl09111
      Location:118 → 207
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    11. XM_039081243.2 → XP_038937171.1  ATR-interacting protein isoform X6

      Conserved Domains (2) summary
      COG0419
      Location:27 → 207
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl09111
      Location:118 → 207
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    12. XM_039081244.2 → XP_038937172.1  ATR-interacting protein isoform X7

      Conserved Domains (2) summary
      COG0419
      Location:27 → 207
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl09111
      Location:118 → 207
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    Nucleotide Protein Strain
    Heading Accession and Version

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