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    Sh3bgrl3 SH3 domain binding glutamate-rich protein like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sh3bgrl3provided by RGD
    Official Full Name
    SH3 domain binding glutamate-rich protein like 3provided by RGD
    Primary source
    RGD:1308118
    See related
    AllianceGenome:RGD:1308118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TIP-B1
    Summary
    Predicted to be involved in cytoskeleton organization. Located in cytosol. Orthologous to human SH3BGRL3 (SH3 domain binding glutamate rich protein like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 297.2), Spleen (RPKM 275.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3bgrl3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151637897..151639270, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146354152..146355525, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152357270..152358643, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1-like Neighboring gene UBX domain protein 11 Neighboring gene centrosomal protein 85 Neighboring gene uncharacterized LOC134487003 Neighboring gene Uromoduilin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression, tissue distribution, and cellular localization of the antiapoptotic TIP-B1 protein. Berleth ES, et al. J Leukoc Biol, 2001 Jun. PMID 11404387
    2. Differential gene expression in nickel(II)-treated normal rat kidney cells. Lee SH. Res Commun Mol Pathol Pharmacol, 2006. PMID 17974098
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nickel(II) treatment down-regulated Sh3bgrl3 expression.
      Title: Differential gene expression in nickel(II)-treated normal rat kidney cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-binding glutamic acid-rich-like protein 3
    Names
    SH3 domain binding glutamic acid-rich protein-like 3
    TNF inhibitory protein B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106688.1 → NP_001100158.1  SH3 domain-binding glutamic acid-rich-like protein 3

      See identical proteins and their annotated locations for NP_001100158.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/Swiss-Prot
      B2RZ27
      UniProtKB/TrEMBL
      A6IT06
      Conserved Domains (1) summary
      pfam04908
      Location:2 → 93
      SH3BGR; SH3-binding, glutamic acid-rich protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151637897..151639270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RZ27.1 GenPept UniProtKB/Swiss-Prot:B2RZ27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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